Polycaprolactone-gelatin nanofibers incorporated with dual antibiotic-loaded carboxyl-modified silica nanoparticles

Zahra Gounani, Sajedeh Pourianejad, Mohammad Ali Asadollahi, Rikke L Meyer, Jessica M Rosenholm, Ayyoob Arpanaei

Research output: Contribution to journalArticleScientificpeer-review

1 Citation (Scopus)

Abstract

In this study, we used electrospun polycaprolactone (PCL) or a mixture of PCL and gelatin (Gel) in a mixed acidic solvent to develop antimicrobial electrospun nanofibers. Carboxyl-modified mesoporous silica nanoparticles (CMSNs) or CMSNs loaded with antibiotic drugs polymyxin B and vancomycin (CMSNs/ABs) were mixed with the electrospinning solution in concentrations of 1%, 2.5% and 5%. The nanofibers diameter measured between 122 and138 nm. Higher concentrations of gelatin or CMSNs increased hydrophilicity and degradability of the nanofibers. CMSNs enhanced nanofibers mechanical strength. PCL/Gel nanofibers incorporated with CMSNs/ABs (2.5% and 5%) showed high antibacterial efficiency against Pseudomonas aeruginosa and Staphylococcus aureus. Also bacterial cell adhesion decreased when 2.5% and 5% of CMSNs/ABs were incorporated in PCL/Gel mats. MTT and hemolysis assays indicated excellent biocompatibility of all types of electrospun nanofibers. This study confirms that a proper mixture of PCL, gelatin and CMSNs loaded with two antibiotics could offer antimicrobial activities with high biocompatibility and biodegradability properties.
Original languageEnglish
Pages (from-to)17134-17150
Number of pages17
JournalJournal of Materials Science
Volume55
Issue number36
DOIs
Publication statusPublished - 21 Sep 2020
MoE publication typeA1 Journal article-refereed

Keywords

  • Mesoporous silica nanoparticle
  • Antibiotics
  • Electrospinning

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