Piercing the Shadows: Exploring the Influence of Signal Preprocessing on Interpreting Ultrasensitive Bioelectronic Sensor Data

Mariapia Caputo, Lucia Sarcina, Cecilia Scandurra, Michele Catacchio, Matteo Piscitelli, Cinzia Di Franco, Paolo Bollella, Gaetano Scamarcio, Luisa Torsi*, Eleonora Macchia*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

The development of ultrasensitive electronic sensors for in vitro diagnostics is essential for the reliable monitoring of asymptomatic individuals before illness proliferation or progression. These platforms are increasingly valued for their potential to enable timely diagnosis and swift prognosis of infectious or progressive diseases. Typically, the responses from these analytical tools are recorded as digital signals, with electronic data offering simpler processing compared to spectral and optical data. However, preprocessing electronic data from potentiometric biosensor arrays is still in its infancy compared to more established optical technologies. This study utilized the Single-Molecule with a Large Transistor (SiMoT) array, which has achieved a Technology Readiness Level of 5, to explore the impact of data preprocessing on electronic biosensor outcomes. A dataset consisting of plasma and cyst fluid samples from 37 patients with pancreatic precursor cyst lesions was analyzed. The findings revealed that standard signal preprocessing can produce misleading conclusions due to artifacts introduced by mathematical transformations. The study offers strategies to mitigate these effects, ensuring that data interpretation remains accurate and reflective of the underlying biochemical information in the samples.

Original languageEnglish
JournalChemPlusChem
DOIs
Publication statusPublished - 2024
MoE publication typeA1 Journal article-refereed

Keywords

  • Chemometric data processing
  • Data preprocessing
  • Electrolyte gated field effect transistors
  • Pancreatic cancer early detection
  • Single molecule with a large transistor-SiMoT

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