Photodynamic Therapy Potential of Ruta chalepensis Extracts: Anticancer and Photosensitizing Effects

Cennet Özay; Emel Bakay; Nermin Topaloglu

doi:10.1117/12.3097786

Photodynamic Therapy Potential of Ruta chalepensis Extracts: Anticancer and Photosensitizing Effects

Cennet Özay^*
, Emel Bakay
, Nermin Topaloglu

^*Corresponding author for this work

Research output: Chapter in Book/Conference proceeding › Published conference proceeding › Scientific › peer-review

Abstract

Ruta chalepensis extract (RCOE) exhibited significant ROS generation under photodynamic therapy, with PDT10 and PDT25 inducing 4-fold and 8-fold increases, respectively. This suggests its potential as a plant-based photosensitizer for PDT applications in cancer treatment.

Original language	English
Title of host publication	Translational Biophotonics
Subtitle of host publication	Diagnostics and Therapeutics IV
Editors	Zhiwei Huang, Lothar D. Lilge
Publisher	Society of Photo-Optical Instrumentation Engineers (SPIE)
ISBN (Electronic)	9781510698055
DOIs	https://doi.org/10.1117/12.3097786
Publication status	Published - 18 Dec 2025
MoE publication type	A4 Article in a conference publication
Event	4th Translational Biophotonics: Diagnostics and Therapeutics - Munich, Germany Duration: 22 Jun 2025 → 26 Jun 2025

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	13934
ISSN (Print)	1605-7422

Conference

Conference	4th Translational Biophotonics: Diagnostics and Therapeutics
Country/Territory	Germany
City	Munich
Period	22/06/25 → 26/06/25

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10.1117/12.3097786

Cite this

Özay, C., Bakay, E., & Topaloglu, N. (2025). Photodynamic Therapy Potential of Ruta chalepensis Extracts: Anticancer and Photosensitizing Effects. In Z. Huang, & L. D. Lilge (Eds.), Translational Biophotonics: Diagnostics and Therapeutics IV Article 139340N (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 13934). Society of Photo-Optical Instrumentation Engineers (SPIE). https://doi.org/10.1117/12.3097786

Özay, Cennet ; Bakay, Emel ; Topaloglu, Nermin. / Photodynamic Therapy Potential of Ruta chalepensis Extracts : Anticancer and Photosensitizing Effects. Translational Biophotonics: Diagnostics and Therapeutics IV. editor / Zhiwei Huang ; Lothar D. Lilge. Society of Photo-Optical Instrumentation Engineers (SPIE), 2025. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).

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title = "Photodynamic Therapy Potential of Ruta chalepensis Extracts: Anticancer and Photosensitizing Effects",

abstract = "Ruta chalepensis extract (RCOE) exhibited significant ROS generation under photodynamic therapy, with PDT10 and PDT25 inducing 4-fold and 8-fold increases, respectively. This suggests its potential as a plant-based photosensitizer for PDT applications in cancer treatment.",

author = "Cennet {\"O}zay and Emel Bakay and Nermin Topaloglu",

note = "Publisher Copyright: {\textcopyright} 2025 The Author(s); 4th Translational Biophotonics: Diagnostics and Therapeutics ; Conference date: 22-06-2025 Through 26-06-2025",

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doi = "10.1117/12.3097786",

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Özay, C, Bakay, E & Topaloglu, N 2025, Photodynamic Therapy Potential of Ruta chalepensis Extracts: Anticancer and Photosensitizing Effects. in Z Huang & LD Lilge (eds), Translational Biophotonics: Diagnostics and Therapeutics IV., 139340N, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 13934, Society of Photo-Optical Instrumentation Engineers (SPIE), 4th Translational Biophotonics: Diagnostics and Therapeutics, Munich, Germany, 22/06/25. https://doi.org/10.1117/12.3097786

Photodynamic Therapy Potential of Ruta chalepensis Extracts: Anticancer and Photosensitizing Effects. / Özay, Cennet; Bakay, Emel; Topaloglu, Nermin.
Translational Biophotonics: Diagnostics and Therapeutics IV. ed. / Zhiwei Huang; Lothar D. Lilge. Society of Photo-Optical Instrumentation Engineers (SPIE), 2025. 139340N (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 13934).

Research output: Chapter in Book/Conference proceeding › Published conference proceeding › Scientific › peer-review

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PY - 2025/12/18

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N2 - Ruta chalepensis extract (RCOE) exhibited significant ROS generation under photodynamic therapy, with PDT10 and PDT25 inducing 4-fold and 8-fold increases, respectively. This suggests its potential as a plant-based photosensitizer for PDT applications in cancer treatment.

AB - Ruta chalepensis extract (RCOE) exhibited significant ROS generation under photodynamic therapy, with PDT10 and PDT25 inducing 4-fold and 8-fold increases, respectively. This suggests its potential as a plant-based photosensitizer for PDT applications in cancer treatment.

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AN - SCOPUS:105025924848

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Translational Biophotonics

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Özay C, Bakay E, Topaloglu N. Photodynamic Therapy Potential of Ruta chalepensis Extracts: Anticancer and Photosensitizing Effects. In Huang Z, Lilge LD, editors, Translational Biophotonics: Diagnostics and Therapeutics IV. Society of Photo-Optical Instrumentation Engineers (SPIE). 2025. 139340N. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.3097786

Photodynamic Therapy Potential of Ruta chalepensis Extracts: Anticancer and Photosensitizing Effects

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