Peptides in lipid bilayers: the power of simple models

J Antoinette Killian, Thomas Nyholm

    Research output: Contribution to journalReview Article or Literature Reviewpeer-review

    135 Citations (Scopus)

    Abstract

    Interactions between proteins and lipids lie at the heart of virtually all membrane processes, but on a molecular level they are still poorly understood. Nowadays, simple model systems comprising designed transmembrane peptides in synthetic lipid bilayers are increasingly being recognized as powerful tools to uncover basic principles of protein-lipid interactions. Such model systems enable detailed analysis of how the properties of lipids influence the structure and dynamics of transmembrane helices, how these helices are anchored at the lipid-water interface, and how the length and composition of transmembrane segments influence the organization and dynamics of membrane lipids. In addition, well-characterized model systems have proven useful to refine computational approaches and to develop new techniques for studies of protein-lipid interactions.
    Original languageUndefined/Unknown
    Pages (from-to)473–479
    JournalCurrent Opinion in Structural Biology
    Volume16
    Issue number4
    DOIs
    Publication statusPublished - 2006
    MoE publication typeA2 Review article in a scientific journal

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