We report literature data indicating that the polyoxyethylene chain of polyoxyethylene detergents attracts cations via dipole-ion interactions thereby attaining a positive charge character. This implies that nonionic polyoxyethylene detergents like Triton X-100 and C12E8 may interact electrostatically with phospholipid head groups. We describe how a positive charge character of Triton X-100 and C12E8 can explain their hitherto mysterious stomatocytogenic shape altering effect in human erythrocytes.
|Number of pages||5|
|Journal||Cellular and Molecular Biology Letters|
|Publication status||Published - 2001|
|MoE publication type||A1 Journal article-refereed|
- erythrocyte membrane
- shape change
- Triton X-100