Oxidation of MC-LR and -RR with chlorine and potassium permanganate: Toxicity of the reaction products

Eva M. Rodríguez; Juan L. Acero; Lisa Spoof; Jussi Meriluoto

doi:10.1016/j.watres.2007.10.039

Oxidation of MC-LR and -RR with chlorine and potassium permanganate: Toxicity of the reaction products

Eva M. Rodríguez^*, Juan L. Acero, Lisa Spoof, Jussi Meriluoto

^*Corresponding author for this work

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Abstract

Toxin-producing cyanobacteria are abundant in surface waters used as drinking water resources. Microcystins (MC) produced by certain cyanobacteria present acute and chronic toxicity, and their removal in drinking water treatment processes is of increasing concern. Previous studies have demonstrated that chlorine and potassium permanganate are feasible oxidants for the removal of MCs present in drinking water resources, although the oxidation might lead to toxic oxidation products. In this paper, the toxicity of the oxidation products of MC-LR and -RR has been studied using protein phosphatase 1 inhibition assay (PPIA). The HPLC and ELISA analyses correlated with the PPIA results for both toxins. The samples containing the oxidation products were fractionated by HPLC and the toxicity of the fractions was tested with PPIA. The results revealed that protein phosphatase 1 inhibition emerged only from intact MC, while the oxidation products were non-toxic. Similar results were obtained in experiments performed in natural waters: no reaction products or interactions exhibiting protein phosphatase 1 inhibition were detected.

Original language	English
Pages (from-to)	1744-1752
Number of pages	9
Journal	Water Research
Volume	42
Issue number	6-7
DOIs	https://doi.org/10.1016/j.watres.2007.10.039
Publication status	Published - Mar 2008
MoE publication type	A1 Journal article-refereed

Keywords

Byproducts
Chlorination
Microcystins
Permanganate oxidation
PPI
Toxicity

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10.1016/j.watres.2007.10.039

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title = "Oxidation of MC-LR and -RR with chlorine and potassium permanganate: Toxicity of the reaction products",

abstract = "Toxin-producing cyanobacteria are abundant in surface waters used as drinking water resources. Microcystins (MC) produced by certain cyanobacteria present acute and chronic toxicity, and their removal in drinking water treatment processes is of increasing concern. Previous studies have demonstrated that chlorine and potassium permanganate are feasible oxidants for the removal of MCs present in drinking water resources, although the oxidation might lead to toxic oxidation products. In this paper, the toxicity of the oxidation products of MC-LR and -RR has been studied using protein phosphatase 1 inhibition assay (PPIA). The HPLC and ELISA analyses correlated with the PPIA results for both toxins. The samples containing the oxidation products were fractionated by HPLC and the toxicity of the fractions was tested with PPIA. The results revealed that protein phosphatase 1 inhibition emerged only from intact MC, while the oxidation products were non-toxic. Similar results were obtained in experiments performed in natural waters: no reaction products or interactions exhibiting protein phosphatase 1 inhibition were detected.",

keywords = "Byproducts, Chlorination, Microcystins, Permanganate oxidation, PPI, Toxicity",

author = "Rodr{\'i}guez, {Eva M.} and Acero, {Juan L.} and Lisa Spoof and Jussi Meriluoto",

note = "Funding Information: This work was supported by the European Commission under the Fifth Framework Programme, research project TOXIC (EVK1-CT-2002-00107). Dr Wido Schmidt is acknowledged as project coordinator. JM and LS thank the Academy of Finland, RC for Biosciences and Environment for financial support (decision number 108947). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2008",

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doi = "10.1016/j.watres.2007.10.039",

language = "English",

volume = "42",

pages = "1744--1752",

journal = "Water Research",

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T1 - Oxidation of MC-LR and -RR with chlorine and potassium permanganate

T2 - Toxicity of the reaction products

AU - Rodríguez, Eva M.

AU - Acero, Juan L.

AU - Spoof, Lisa

AU - Meriluoto, Jussi

N1 - Funding Information: This work was supported by the European Commission under the Fifth Framework Programme, research project TOXIC (EVK1-CT-2002-00107). Dr Wido Schmidt is acknowledged as project coordinator. JM and LS thank the Academy of Finland, RC for Biosciences and Environment for financial support (decision number 108947). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2008/3

Y1 - 2008/3

N2 - Toxin-producing cyanobacteria are abundant in surface waters used as drinking water resources. Microcystins (MC) produced by certain cyanobacteria present acute and chronic toxicity, and their removal in drinking water treatment processes is of increasing concern. Previous studies have demonstrated that chlorine and potassium permanganate are feasible oxidants for the removal of MCs present in drinking water resources, although the oxidation might lead to toxic oxidation products. In this paper, the toxicity of the oxidation products of MC-LR and -RR has been studied using protein phosphatase 1 inhibition assay (PPIA). The HPLC and ELISA analyses correlated with the PPIA results for both toxins. The samples containing the oxidation products were fractionated by HPLC and the toxicity of the fractions was tested with PPIA. The results revealed that protein phosphatase 1 inhibition emerged only from intact MC, while the oxidation products were non-toxic. Similar results were obtained in experiments performed in natural waters: no reaction products or interactions exhibiting protein phosphatase 1 inhibition were detected.

AB - Toxin-producing cyanobacteria are abundant in surface waters used as drinking water resources. Microcystins (MC) produced by certain cyanobacteria present acute and chronic toxicity, and their removal in drinking water treatment processes is of increasing concern. Previous studies have demonstrated that chlorine and potassium permanganate are feasible oxidants for the removal of MCs present in drinking water resources, although the oxidation might lead to toxic oxidation products. In this paper, the toxicity of the oxidation products of MC-LR and -RR has been studied using protein phosphatase 1 inhibition assay (PPIA). The HPLC and ELISA analyses correlated with the PPIA results for both toxins. The samples containing the oxidation products were fractionated by HPLC and the toxicity of the fractions was tested with PPIA. The results revealed that protein phosphatase 1 inhibition emerged only from intact MC, while the oxidation products were non-toxic. Similar results were obtained in experiments performed in natural waters: no reaction products or interactions exhibiting protein phosphatase 1 inhibition were detected.

KW - Byproducts

KW - Chlorination

KW - Microcystins

KW - Permanganate oxidation

KW - PPI

KW - Toxicity

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ER -

Oxidation of MC-LR and -RR with chlorine and potassium permanganate: Toxicity of the reaction products

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