Oxidation of MC-LR and -RR with chlorine and potassium permanganate: Toxicity of the reaction products

Eva M. Rodríguez*, Juan L. Acero, Lisa Spoof, Jussi Meriluoto

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

69 Citations (Scopus)

Abstract

Toxin-producing cyanobacteria are abundant in surface waters used as drinking water resources. Microcystins (MC) produced by certain cyanobacteria present acute and chronic toxicity, and their removal in drinking water treatment processes is of increasing concern. Previous studies have demonstrated that chlorine and potassium permanganate are feasible oxidants for the removal of MCs present in drinking water resources, although the oxidation might lead to toxic oxidation products. In this paper, the toxicity of the oxidation products of MC-LR and -RR has been studied using protein phosphatase 1 inhibition assay (PPIA). The HPLC and ELISA analyses correlated with the PPIA results for both toxins. The samples containing the oxidation products were fractionated by HPLC and the toxicity of the fractions was tested with PPIA. The results revealed that protein phosphatase 1 inhibition emerged only from intact MC, while the oxidation products were non-toxic. Similar results were obtained in experiments performed in natural waters: no reaction products or interactions exhibiting protein phosphatase 1 inhibition were detected.

Original languageEnglish
Pages (from-to)1744-1752
Number of pages9
JournalWater Research
Volume42
Issue number6-7
DOIs
Publication statusPublished - Mar 2008
MoE publication typeA1 Journal article-refereed

Keywords

  • Byproducts
  • Chlorination
  • Microcystins
  • Permanganate oxidation
  • PPI
  • Toxicity

Fingerprint

Dive into the research topics of 'Oxidation of MC-LR and -RR with chlorine and potassium permanganate: Toxicity of the reaction products'. Together they form a unique fingerprint.

Cite this