Oromucosal films: from patient centricity to production by printing techniques

Yu Tian, Mine Orlu, Herman J. Woerdenbag, Mariagiovanna Scarpa, Olga Kiefer, Dina Kottke, Erica Sjöholm, Heidi Öblom, Niklas Sandler, Wouter L. J. Hinrichs, Henderik W. Frijlink, Jörg Breitkreutz. J. Carolina Visser

Research output: Contribution to journalReview Article or Literature Reviewpeer-review

36 Citations (Scopus)
30 Downloads (Pure)


Introduction: Oromucosal films, comprising mucoadhesive buccal films (MBFs) and orodispersible films (ODFs), are considered patient-centric dosage forms. Target groups are patients with special needs. Various active pharmaceutical ingredients have been shown to be suitable for oromucosal film production. A shift is seen in the production techniques, from conventional solvent casting to printing techniques.

Areas covered: In this review, the patient acceptability of oromucosal films is discussed. An overview is given of the small molecule drugs, biopharmaceuticals and herbal extracts that have been incorporated so far. Finally, the current state of 2D and 3D printing techniques for production purposes is discussed.

Expert opinion: The patient-centric features are important for the further development and acceptance of this oral solid dosage form. Oromucosal films perfectly fit in the current attention for personalized medicine. Both MBFs and ODFs are intended for either a local or a systemic effect. For buccal absorption, sufficient mucoadhesion is one of the most important criteria an oromucosal film must comply with. For the preparation, the solvent casting technique is still predominately used. Some limitations of this production method can be tackled by printing techniques. However, these novel techniques introduce new requirements, yet to be set, for oromucosal film preparation.

Original languageUndefined/Unknown
Pages (from-to)981–993
JournalExpert Opinion on Drug Delivery
Issue number9
Publication statusPublished - 2019
MoE publication typeA2 Review article in a scientific journal


  • drug delivery
  • printing techniques
  • patient centricity
  • Local drug delivery
  • mucoadhesive buccal films
  • orodispersible films
  • oromucosal films

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