Projects per year
Abstract
Orodispersible films (ODFs) are ultra-thin, stamp-sized, elegant, portable and patient-centric pharmaceutical dosage forms that do not need water to be ingested. They are particularly useful for paediatric and geriatric patient populations with special needs such as dysphagia, Parkinson’s disease, and oral cancer. Accordingly, they hold tremendous potential in gaining patient compliance, convenience and pharmacotherapy. In the present review, conception and evolution of ODFs as a product and its technology are discussed. The review continues by providing overview about the potential of ODFs as carriers for delivering drugs, herbal extracts, probiotics and vaccines. Besides, strategies employed in drug cargo loading, taste masking of bitter drugs and enhancing drug stability are discussed. Finally, the review concludes by providing a brief overview about quality by design (QbD) principles in development of ODFs.
Original language | English |
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Article number | 113983 |
Journal | Advanced Drug Delivery Reviews |
Volume | 178 |
DOIs | |
Publication status | Published - Nov 2021 |
MoE publication type | A2 Review article in a scientific journal |
Keywords
- Patient-centric
- Probiotics
- Vaccines
- Quality by design
- ODF
- QbD
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Åbo Akademi Functional Printing Center
Toivakka, M. (PI), Rosenholm, J. (PI), Anttu, N. (PI), Bobacka, J. (PI), Huynh, T. P. (PI), Peltonen, J. (PI), Wang, X. (PI), Wilen, C.-E. (PI), Xu, C. (PI), Zhang, H. (PI) & Österbacka, R. (PI)
Faculty of Science and EngineeringFacility/equipment: Facility
Projects
- 1 Finished
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AMBioPharma: Centre for Additive Manufacturing for Life Science and Pharmaceutical Industry
Rosenholm, J. (Principal Investigator), Xu, C. (Principal Investigator), Wang, X. (Co-Investigator) & Palo, M. (Co-Investigator)
01/09/21 → 31/08/23
Project: EU