Opportunities and Challenges of Silicon‐based Nanoparticles for Drug Delivery and Imaging

Didem Şen Karaman, Martti Kaasalainen, Helene Kettiger, Jessica M Rosenholm

Research output: Chapter in Book/Conference proceedingChapterScientificpeer-review

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Abstract

Silica nanoparticles are a type of colloidal amorphous metal oxide, which can be synthesized by a bottom‐up approach via the sol‐gel process. This chapter presents different architectures of silica nanoparticles (NPs), including nonporous silica NPs, mesoporous silica NPs, hollow silica NPs, and porous silica NPs, along with case studies of drug delivery and imaging from the literature. The chapter discusses the solid‐state characterization and medium‐dependent characterization of silica NPs. Trends in combinatorial chemistry and new approaches in drug design have resulted in more lipophilic potential drug compounds. The physical properties, surface modifications, and composition of porous and nonporous silicon‐based NPs can be tuned in order to make them powerful tools for imaging. Among all the molecular imaging modalities, optical imaging has been a versatile and easy‐to‐use approach in terms of available imaging agents to be used and relatively low cost of instrumentation.
Original languageEnglish
Title of host publicationCharacterization of Pharmaceutical Nano and Microsystems
EditorsLeena Peltonen
PublisherJohn Wiley & Sons
Chapter9
Pages291-337
Number of pages47
ISBN (Electronic)9781119414018
ISBN (Print)9781119414049
DOIs
Publication statusPublished - 30 Oct 2020
MoE publication typeA3 Part of a book or another research book

Publication series

NameCharacterization of Pharmaceutical Nano and Microsystems
PublisherJohn Wiley & Sons, Ltd Chichester, UK

Keywords

  • Mesoporous silica nanoparticles
  • imaging
  • bioimaging
  • Drug delivery
  • Drug delivery systems
  • Silica

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