One-pot utilization of heterogeneous and enzymatic catalysis: Synthesis of R-1-phenylethyl acetate from acetophenone

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Abstract

One-pot synthesis of R-1-phenylethyl acetate was investigated starting from hydrogenation of acetophenone over a metal-supported catalyst followed by acylation of the formed R-1-phenylethanol over an immobilized lipase. The most promising catalyst for the hydrogenation step was Pd/Al2O3, which in combination with an immobilized lipase yielded maximally 22% R-1-phenylethyl acetate. The support acidity had a crucial effect on the selectivity towards the desired product.

Original languageEnglish
Pages (from-to)70-73
Number of pages4
JournalCatalysis Today
Volume140
Issue number1-2
DOIs
Publication statusPublished - 15 Feb 2009
MoE publication typeA1 Journal article-refereed

Keywords

  • Acylation
  • Heterogeneous catalyst
  • Hydrogenation
  • One-pot synthesis

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