One-pot utilization of heterogeneous and enzymatic catalysis: Synthesis of R-1-phenylethyl acetate from acetophenone

Päivi Mäki-Arvela; Serap Sahin; Narendra Kumar; Jyri-Pekka Mikkola; Kari Eränen; Tapio Salmi; Dmitry Yu. Murzin

doi:10.1016/j.cattod.2008.07.037

One-pot utilization of heterogeneous and enzymatic catalysis: Synthesis of R-1-phenylethyl acetate from acetophenone

Päivi Mäki-Arvela, Serap Sahin, Narendra Kumar, Jyri-Pekka Mikkola, Kari Eränen, Tapio Salmi, Dmitry Yu. Murzin^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

14 Citations (Scopus)

Abstract

One-pot synthesis of R-1-phenylethyl acetate was investigated starting from hydrogenation of acetophenone over a metal-supported catalyst followed by acylation of the formed R-1-phenylethanol over an immobilized lipase. The most promising catalyst for the hydrogenation step was Pd/Al₂O₃, which in combination with an immobilized lipase yielded maximally 22% R-1-phenylethyl acetate. The support acidity had a crucial effect on the selectivity towards the desired product.

Original language	English
Pages (from-to)	70-73
Number of pages	4
Journal	Catalysis Today
Volume	140
Issue number	1-2
DOIs	https://doi.org/10.1016/j.cattod.2008.07.037
Publication status	Published - 15 Feb 2009
MoE publication type	A1 Journal article-refereed

Keywords

Acylation
Heterogeneous catalyst
Hydrogenation
One-pot synthesis

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title = "One-pot utilization of heterogeneous and enzymatic catalysis: Synthesis of R-1-phenylethyl acetate from acetophenone",

abstract = "One-pot synthesis of R-1-phenylethyl acetate was investigated starting from hydrogenation of acetophenone over a metal-supported catalyst followed by acylation of the formed R-1-phenylethanol over an immobilized lipase. The most promising catalyst for the hydrogenation step was Pd/Al2O3, which in combination with an immobilized lipase yielded maximally 22% R-1-phenylethyl acetate. The support acidity had a crucial effect on the selectivity towards the desired product.",

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AU - Mäki-Arvela, Päivi

AU - Sahin, Serap

AU - Kumar, Narendra

AU - Mikkola, Jyri-Pekka

AU - Eränen, Kari

AU - Salmi, Tapio

AU - Murzin, Dmitry Yu.

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Y1 - 2009/2/15

N2 - One-pot synthesis of R-1-phenylethyl acetate was investigated starting from hydrogenation of acetophenone over a metal-supported catalyst followed by acylation of the formed R-1-phenylethanol over an immobilized lipase. The most promising catalyst for the hydrogenation step was Pd/Al2O3, which in combination with an immobilized lipase yielded maximally 22% R-1-phenylethyl acetate. The support acidity had a crucial effect on the selectivity towards the desired product.

AB - One-pot synthesis of R-1-phenylethyl acetate was investigated starting from hydrogenation of acetophenone over a metal-supported catalyst followed by acylation of the formed R-1-phenylethanol over an immobilized lipase. The most promising catalyst for the hydrogenation step was Pd/Al2O3, which in combination with an immobilized lipase yielded maximally 22% R-1-phenylethyl acetate. The support acidity had a crucial effect on the selectivity towards the desired product.

KW - Acylation

KW - Heterogeneous catalyst

KW - Hydrogenation

KW - One-pot synthesis

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SN - 0920-5861

VL - 140

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JO - Catalysis Today

JF - Catalysis Today

IS - 1-2

ER -

One-pot utilization of heterogeneous and enzymatic catalysis: Synthesis of R-1-phenylethyl acetate from acetophenone

Abstract

Keywords

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