One-pot synthesis of pore-expanded hollow mesoporous silica particles

Didem Sen Karaman, Tina Gulin-Sarfraz, Jixi Zhang, Jessica Rosenholm

Research output: Contribution to journalArticleScientificpeer-review

18 Citations (Scopus)


One-pot hard/soft template-free synthesis of hollow structured mesoporous silica particles (H-MSPs) with enlarged pore sizes was developed. By a simplified in situ hydrothermal treatment under mild conditions (70 °C), a hollow interior evolution to a final size of ~150 nm was successfully induced for the as-prepared particles from the sol–gel synthesis solution. The particles were evenly spherical with an average particle diameter of 350 nm, as well as a mean pore size of 5 nm in the mesoporous shell. Pore-swelling agents and aminosilane were demonstrated to contribute to the chemical irregularities in the silica network formation during particle growth, consequently leading to selective dissolution of the interior silica.
Original languageUndefined/Unknown
Pages (from-to)140–143
JournalMaterials Letters
Publication statusPublished - 2015
MoE publication typeA1 Journal article-refereed


  • porous materials
  • sol-gel
  • Drug delivery systems

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