Ocular Drug Delivery: Introduction and Fundamental Concept

Omar Khan; Rohit Bhawale; Kshitiz Luthra; Vaibhavi Srivastava; Kuldeep Kumar Bansal; Vivek Gupta; Neelesh Kumar Mehra

doi:10.1007/978-981-96-6306-4_1

Ocular Drug Delivery: Introduction and Fundamental Concept

Omar Khan
, Rohit Bhawale
, Kshitiz Luthra
, Vaibhavi Srivastava
, Kuldeep Kumar Bansal
, Vivek Gupta
, Neelesh Kumar Mehra^*

^*Corresponding author for this work

Research output: Chapter in Book/Conference proceeding › Chapter › Scientific › peer-review

2 Citations (Scopus)

Abstract

Ocular diseases are one of the most serious concerns worldwide, with more than 45 million cases of blindness, significantly affecting the vision and quality of life of the patients. However, effective drug delivery to the eyes remains challenging, especially to the posterior region of the eye due to the presence of various ocular barriers. This led to various advancements in the development of various novel ocular therapeutics with superior efficacy and safety. This chapter highlights the basics of ocular drug delivery systems (ODDS) including the anatomy of the eyes and their physiological barriers affecting the drug delivery, various invasive and noninvasive routes of ocular drug administration, a brief overview of ocular diseases, their complications, and various conventional and novel ODDS. Regulatory perspectives of ODDS, overview of marketed ophthalmic products, and recently approved patents along with the future perspectives in design and development of safe and effective ODDS have also been addressed in this chapter.

Original language	English
Title of host publication	Complex Ophthalmic Dosage Forms
Subtitle of host publication	Advances in Biomedical Applications and Future Perspectives
Publisher	Springer
Pages	1-44
Number of pages	44
ISBN (Electronic)	9789819663064
ISBN (Print)	9789819663057
DOIs	https://doi.org/10.1007/978-981-96-6306-4_1
Publication status	Published - 1 Jan 2025
MoE publication type	A3 Part of a book or another research book

Keywords

Intraocular drug delivery
Micelles
Ocular barriers
Ocular diseases
Ocular drug delivery systems
Polymeric nanoparticles

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10.1007/978-981-96-6306-4_1

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title = "Ocular Drug Delivery: Introduction and Fundamental Concept",

abstract = "Ocular diseases are one of the most serious concerns worldwide, with more than 45 million cases of blindness, significantly affecting the vision and quality of life of the patients. However, effective drug delivery to the eyes remains challenging, especially to the posterior region of the eye due to the presence of various ocular barriers. This led to various advancements in the development of various novel ocular therapeutics with superior efficacy and safety. This chapter highlights the basics of ocular drug delivery systems (ODDS) including the anatomy of the eyes and their physiological barriers affecting the drug delivery, various invasive and noninvasive routes of ocular drug administration, a brief overview of ocular diseases, their complications, and various conventional and novel ODDS. Regulatory perspectives of ODDS, overview of marketed ophthalmic products, and recently approved patents along with the future perspectives in design and development of safe and effective ODDS have also been addressed in this chapter.",

keywords = "Intraocular drug delivery, Micelles, Ocular barriers, Ocular diseases, Ocular drug delivery systems, Polymeric nanoparticles",

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AU - Khan, Omar

AU - Bhawale, Rohit

AU - Luthra, Kshitiz

AU - Srivastava, Vaibhavi

AU - Bansal, Kuldeep Kumar

AU - Gupta, Vivek

AU - Mehra, Neelesh Kumar

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N2 - Ocular diseases are one of the most serious concerns worldwide, with more than 45 million cases of blindness, significantly affecting the vision and quality of life of the patients. However, effective drug delivery to the eyes remains challenging, especially to the posterior region of the eye due to the presence of various ocular barriers. This led to various advancements in the development of various novel ocular therapeutics with superior efficacy and safety. This chapter highlights the basics of ocular drug delivery systems (ODDS) including the anatomy of the eyes and their physiological barriers affecting the drug delivery, various invasive and noninvasive routes of ocular drug administration, a brief overview of ocular diseases, their complications, and various conventional and novel ODDS. Regulatory perspectives of ODDS, overview of marketed ophthalmic products, and recently approved patents along with the future perspectives in design and development of safe and effective ODDS have also been addressed in this chapter.

AB - Ocular diseases are one of the most serious concerns worldwide, with more than 45 million cases of blindness, significantly affecting the vision and quality of life of the patients. However, effective drug delivery to the eyes remains challenging, especially to the posterior region of the eye due to the presence of various ocular barriers. This led to various advancements in the development of various novel ocular therapeutics with superior efficacy and safety. This chapter highlights the basics of ocular drug delivery systems (ODDS) including the anatomy of the eyes and their physiological barriers affecting the drug delivery, various invasive and noninvasive routes of ocular drug administration, a brief overview of ocular diseases, their complications, and various conventional and novel ODDS. Regulatory perspectives of ODDS, overview of marketed ophthalmic products, and recently approved patents along with the future perspectives in design and development of safe and effective ODDS have also been addressed in this chapter.

KW - Intraocular drug delivery

KW - Micelles

KW - Ocular barriers

KW - Ocular diseases

KW - Ocular drug delivery systems

KW - Polymeric nanoparticles

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Ocular Drug Delivery: Introduction and Fundamental Concept

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Keywords

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