Nuclear stress granules: the awakening of a sleeping beauty?

Anton Sandqvist, Lea Sistonen

Research output: Contribution to journalReview Article or Literature Reviewpeer-review


Nuclear stress granules are subnuclear compartments that form in response to heat shock and other stress stimuli. Although many components of nuclear stress granules have been identified, including HSF1 and pre-mRNA processing factors, their function remains a mystery. A paper in this issue describes the stress-induced transcriptional activation of one of the nuclear stress granule target sites, a heterochromatic region that has been considered silent (Jolly et al., 2004). These intriguing findings will certainly give the research of these structures a new twist.

Original languageEnglish
Pages (from-to)15-7
Number of pages3
JournalJournal of Cell Biology
Issue number1
Publication statusPublished - 5 Jan 2004
MoE publication typeA2 Review article in a scientific journal


  • Animals
  • Cell Nucleus Structures/genetics
  • Chromosomes, Human, Pair 9/genetics
  • DNA, Satellite/genetics
  • DNA-Binding Proteins/genetics
  • Heat Shock Transcription Factors
  • Heterochromatin/genetics
  • Humans
  • RNA Precursors/genetics
  • Stress, Physiological/genetics
  • Transcription Factors
  • Transcriptional Activation/genetics


Dive into the research topics of 'Nuclear stress granules: the awakening of a sleeping beauty?'. Together they form a unique fingerprint.

Cite this