Niosomes-Based Drug Delivery in Targeting the Brain Tumors Via Nasal Delivery

Mahmoud Gharbavi, Sepideh Parvanian, Milad Parvinzad Leilan, Shabnam Tavangar, Maedeh Parchianlou, Ali Sharafi*

*Corresponding author for this work

Research output: Chapter in Book/Conference proceedingChapterScientificpeer-review

4 Citations (Scopus)

Abstract

Targeting tumors has always been a herculean task. Moreover, the presence of blood brain barrier (BBB) acts as a physical barrier and restricts the transportation of therapeutic molecules across the brain. Targeted delivery of the therapeutic payload across the blood brain barrier has gained widespread attention over the past few years. Intranasal route offers delivery to the brain via the trigeminal and olfactory route surpassing BBB. It also offers various other advantages such as surpassing biotransformation, and systemic absorption increasing the efficacy. Over the last few decades, several novel drug delivery systems such as liposomes and other lipid nanoparticles targeting brain, have gained widespread attention. The Niosomes are vesicular nanoparticle flatforms comprised of non-ionic surfactants, which are biodegradable, more stable than liposomes. This current review discusses the potential use of niosomes as a delivery vehicle for targeting brain tumors via the nasal route.

Original languageEnglish
Title of host publicationNasal Drug Delivery
Subtitle of host publicationFormulations, Developments, Challenges, and Solutions
PublisherSpringer International Publishing
Pages279-324
Number of pages46
ISBN (Electronic)9783031231124
ISBN (Print)9783031231117
DOIs
Publication statusPublished - 18 Mar 2023
MoE publication typeA3 Part of a book or another research book

Keywords

  • Blood brain barrier
  • Nanoparticles
  • Nasal route
  • Niosomes
  • Tumours

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