Using psychoanalysis as a starting point, we explore the value of therapeutic neutrality in psychotherapies that seek to foster self-understanding, experiencing, and insight. Contrary to much of the current zeitgeist, therapist neutrality is posited to be a key element of effective psychotherapy in such approaches. We suggest 5 meanings of effective therapeutic neutrality: The therapist (a) takes, at least in part, an observer position in the relationship; (b) refrains from taking sides in the patient’s inner struggles; (c) also does not take sides in the patient’s relational struggles; (d) refrains from manipulating the patient into emotional expression; and (e) follows some guide- lines about when to directly gratify the patient’s dependency and affectional needs/demands. Rules of thumb are presented about the conditions under which direct gratification is called for. However, as a bottom line, if neutrality is to be an effective stance in any psychotherapy, it must be carried out in the context of empathy, caring, and affirmation.