Network analytics for drug repurposing in COVID-19

Nicoleta Siminea, Victor Popescu, Jose Angel Sanchez Martin, Daniela Florea, Georgiana Gavril, Ana-Maria Gheorghe, Corina Iţcuş, Krishna Kanhaiya, Octavian Pacioglu, Laura Ioana Popa, Romica Trandafir, Maria Iris Tusa, Manuela Sidoroff, Mihaela Pãun, Eugen Czeizler, Andrei Pãun, Ion Petre*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

16 Citations (Scopus)
17 Downloads (Pure)

Abstract

To better understand the potential of drug repurposing in COVID-19, we analyzed control strategies over essential host factors for SARS-CoV-2 infection. We constructed comprehensive directed protein-protein interaction (PPI) networks integrating the top-ranked host factors, the drug target proteins and directed PPI data. We analyzed the networks to identify drug targets and combinations thereof that offer efficient control over the host factors. We validated our findings against clinical studies data and bioinformatics studies. Our method offers a new insight into the molecular details of the disease and into potentially new therapy targets for it. Our approach for drug repurposing is significant beyond COVID-19 and may be applied also to other diseases.

Original languageEnglish
Article numberbbab490
JournalBriefings in Bioinformatics
Volume23
Issue number1
DOIs
Publication statusPublished - 1 Jan 2022
MoE publication typeA1 Journal article-refereed

Keywords

  • COVID-19
  • drug repurposing
  • host factors
  • network biology
  • network controllability

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