Natural origin microfiber scaffolds from microfluidic spinning for gastric tumor postsurgical treatment

Biomedical scaffolds have recently emerged as promising postoperative treatment platforms in the field of oncology. In this study, we propose novel natural-origin scaffolds encapsulating Huachansu to treat gastric cancer (GC) in postsurgical. The scaffold, characterized by a well-woven mesh structure, is fabricated using microfluidic spinning and ion cross-linking of Premna Microphylla, a Chinese medicine derived from herbs. These natural-origin ingredients enable the scaffolds with good biocompatibility. In a GC post-surgical model in nude mice, the microfiber scaffolds could significantly inhibit GC tumor recurrence following tumor resection. Furthermore, the natural-origin scaffolds could effectively repair stomach damage in the gastrotomy model. Given these promising features, the natural-origin microfiber scaffolds hold significant potential in biomedicine, particularly in comprehensive post-surgical treatments for GC.