Multisite phosphorylation provides sophisticated regulation of transcription factors

CI Holmberg, Tran SEF, John Eriksson, Lea Sistonen

    Research output: Contribution to journalArticleScientificpeer-review

    104 Citations (Scopus)

    Abstract

    Reversible phosphorylation is a prevalent mechanism by which the activity of eukaryotic transcription factors is regulated rapidly in response to changes in the cellular environment. Accumulated evidence has expanded the concept of phosphorylation to a process that provides dynamic and precise tuning of the transactivating potential of a factor, rather than being a static on/off switch. In the case of transcription factors such as heat shock factor 1 (HSF1), p53 and nuclear factor of activated T cells (NFAT), multisite phosphorylation enables several effects to operate within a single factor, thereby functioning as a key to signal integration. Studies on these transcription factors illustrate recent progress in solving the dynamic nature of transcriptional regulation by multisite phosphorylation.
    Original languageUndefined/Unknown
    Pages (from-to)619–627
    Number of pages9
    JournalTrends in Biochemical Sciences
    Volume27
    Issue number12
    Publication statusPublished - 2002
    MoE publication typeA1 Journal article-refereed

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