Abstract
Reversible phosphorylation is a prevalent mechanism by which the activity of eukaryotic transcription factors is regulated rapidly in response to changes in the cellular environment. Accumulated evidence has expanded the concept of phosphorylation to a process that provides dynamic and precise tuning of the transactivating potential of a factor, rather than being a static on/off switch. In the case of transcription factors such as heat shock factor 1 (HSF1), p53 and nuclear factor of activated T cells (NFAT), multisite phosphorylation enables several effects to operate within a single factor, thereby functioning as a key to signal integration. Studies on these transcription factors illustrate recent progress in solving the dynamic nature of transcriptional regulation by multisite phosphorylation.
Original language | English |
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Pages (from-to) | 619–627 |
Number of pages | 9 |
Journal | Trends in Biochemical Sciences |
Volume | 27 |
Issue number | 12 |
DOIs | |
Publication status | Published - Dec 2002 |
MoE publication type | A2 Review article in a scientific journal |
Keywords
- Animals
- DNA-Binding Proteins/metabolism
- Humans
- NFATC Transcription Factors
- Nuclear Proteins
- Phosphorylation
- Protein Biosynthesis
- Transcription Factors/chemistry
- Transcriptional Activation