Multimodality Imaging of Silica and Silicon Materials In Vivo

Didem Sen Karaman, MP Sarparanta, Jessica Rosenholm, AJ Airaksinen

Research output: Contribution to journalReview Article or Literature ReviewScientificpeer-review

28 Citations (Scopus)

Abstract

Recent progress in the development of silica-and silicon-based multimodality imaging nanoprobes has advanced their use in image-guided drug delivery, and the development of novel systems for nanotheranostic and diagnostic applications. As biocompatible and flexibly tunable materials, silica and silicon provide excellent platforms with high clinical potential in nanotheranostic and diagnostic probes with well-defined morphology and surface chemistry, yielding multifunctional properties. In vivo imaging is of great value in the exploration of methods for improving site-specific nanotherapeutic delivery by silica-and silicon-based drug-delivery systems. Multimodality approaches are essential for understanding the biological interactions of nanotherapeutics in the physiological environment in vivo. The aim here is to describe recent advances in the development of in vivo imaging tools based on nanostructured silica and silicon, and their applications in single and multimodality imaging.
Original languageUndefined/Unknown
Pages (from-to)
Number of pages26
JournalAdvanced Materials
Volume30
Issue number24
DOIs
Publication statusPublished - 2018
MoE publication typeA2 Review article in a scientific journal

Keywords

  • image-guided drug delivery
  • nanotheranostics
  • mesoporous silica nanoparticles

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