Molecular Mechanisms of Heat Shock Factors in Cancer

Mikael Christer Puustinen, Lea Sistonen

Research output: Contribution to journalReview Article or Literature Reviewpeer-review

32 Citations (Scopus)


Malignant transformation is accompanied by alterations in the key cellular pathways that regulate development, metabolism, proliferation and motility as well as stress resilience. The members of the transcription factor family, called heat shock factors (HSFs), have been shown to play important roles in all of these biological processes, and in the past decade it has become evident that their activities are rewired during tumorigenesis. This review focuses on the expression patterns and functions of HSF1, HSF2, and HSF4 in specific cancer types, highlighting the mechanisms by which the regulatory functions of these transcription factors are modulated. Recently developed therapeutic approaches that target HSFs are also discussed.
Original languageEnglish
Article number1202
Issue number5
Publication statusPublished - 2020
MoE publication typeA2 Review article in a scientific journal


  • Animals
  • Heat-Shock Proteins/metabolism
  • Humans
  • Models, Biological
  • Neoplasm Invasiveness
  • Neoplasms/chemistry
  • Protein Domains


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