Molecular drug targets for scabies: a medicinal chemistry perspective

Wali Inam, Shelley Walton, Sheraz Khan, Wajahat Mahmood

Research output: Contribution to journalReview Article or Literature ReviewScientificpeer-review

Abstract

Sarcoptes scabiei is a causative organism for scabies that affects an estimated global population of 300 million and remains a disease of significant concern. Recently, a number of potential drug targets were identified for scabies, including hydrolytic enzymes, inactivated paralogues of hydrolytic enzymes, inhibitors of host proteolytic enzymes and other proteins of interest. These discoveries remain confined to academic laboratories and institutions, failing to attract interest from researchers in commercial drug development. Here, we summarize the latest developments in the scabies mite biology and the drug targets that were subsequently identified, and we propose several peptide and nonpeptide ligands targeting the hot spots for protein?protein interactions. We also identify gaps in the development of ligands as inhibitors or modulators of these macromolecules.
Original languageEnglish
Pages (from-to)2225-2238
Number of pages14
JournalFuture Medicinal Chemistry
Volume12
Issue number24
DOIs
Publication statusPublished - 27 Nov 2020
MoE publication typeA2 Review article in a scientific journal

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