Projects per year
Cancer is a global public health concern. Alterations in epigenetic processes are among the earliest genomic aberrations occurring during cancer development and are closely related to progression. Unlike genetic mutations, aberrations in epigenetic processes are reversible, which opens the possibility for novel pharmacological treatments. Non‑coding RNAs (ncRNAs) represent an essential epigenetic mechanism, and emerging evidence links ncRNAs to carcinogenesis. Epigenetic drugs (epidrugs) are a group of promising target therapies for cancer treatment acting as coadjuvants to reverse drug resistance in cancer. The present review describes central epigenetic aberrations during malignant transformation and explains how epidrugs target DNA methylation, histone modifications and ncRNAs. Furthermore, clinical trials focused on evaluating the effect of these epidrugs alone or in combination with other anticancer therapies and other ncRNA‑based therapies are discussed. The use of epidrugs promises to be an effective tool for reversing drug resistance in some patients with cancer.
|Publication status||Published - Mar 2023|
|MoE publication type||A2 Review article in a scientific journal|
- Epigenesis, Genetic
- DNA Methylation
- Neoplasms/drug therapy
- RNA, Untranslated/metabolism
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- 2 Active
Notch counteracts replication stress to prevent cancer cell senescence
Cancer Foundation Finland, Sigrid Jusélius Foundation
01/05/20 → 31/12/23
CellMech: Center of Excellence in Cellular Mechanostasis
Sahlgren, C., Sistonen, L., Eriksson, J., Toivola, D., Meinander, A., Cheng, F. & Jacquemet, G.
01/03/19 → 29/02/24