Modeling of a hybrid Langmuir adsorption isotherm for describing interactions between drug molecules and silica surfaces

Thomas Sandberg, Christian Weinberger, Didem Sen Karaman, Jessica Rosenholm

Research output: Contribution to journalArticleScientificpeer-review

10 Citations (Scopus)
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The interaction between disulfiram (Antabus®) and silica was studied experimentally by adsorption from apolar solvent onto highly porous silica material (Santa Barbara Amorphous material-3, SBA-3) with large surface area. The adsorption isotherm was fitted to the Langmuir model by accounting two different affinities contributing to the overall behavior, which were attributed to two different types of silanol groups (i.e. geminal and vicinal) present on amorphous silica surfaces. This assumption was supported by theoretical calculations. Additionally, the model could describe the adsorption of ibuprofen to the carrier material, indicating that the model bears big potential for describing the interactions between silica surfaces and drug molecules.

Original languageUndefined/Unknown
Pages (from-to)1392–1397
JournalJournal of Pharmaceutical Sciences
Issue number5
Publication statusPublished - 2018
MoE publication typeA1 Journal article-refereed


  • Ab initio calculations
  • Adsorption
  • Silica

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