Microglia from patients with multiple sclerosis display a cell-autonomous immune activation state

Tanja Hyvarinen; Johanna Tilvis; Luca Giudice; Iisa Tujula; Marjo Nylund; Sohvi Ohtonen; Flavia Scoyni; Henna Jantti; Lassi Virtanen; Sara Pihlava; Roosa Kattelus; Heli Skottman; Susanna Narkilahti; Laura Airas; Tarja Malm; Sanna Hagman

doi:10.1186/s12974-025-03575-4

Microglia from patients with multiple sclerosis display a cell-autonomous immune activation state

Tanja Hyvarinen
, Johanna Tilvis
, Luca Giudice
, Iisa Tujula
, Marjo Nylund
, Sohvi Ohtonen
, Flavia Scoyni
, Henna Jantti
, Lassi Virtanen
, Sara Pihlava
, Roosa Kattelus
, Heli Skottman
, Susanna Narkilahti
, Laura Airas
, Tarja Malm
, Sanna Hagman

Research output: Contribution to journal › Article › Scientific › peer-review

2 Citations (Scopus)

Original language	English
Article number	255
Number of pages	21
Journal	Journal of Neuroinflammation
Volume	22
Issue number	1
DOIs	https://doi.org/10.1186/s12974-025-03575-4
Publication status	Published - 31 Oct 2025
MoE publication type	A1 Journal article-refereed

Keywords

Human induced pluripotent stem cells
Microglia
Multiple sclerosis
Neuroinflammation

Access to Document

10.1186/s12974-025-03575-4Licence: CC BY

s12974-025-03575-4Final published version, 9.42 MBLicence: CC BY

https://urn.fi/URN:NBN:fi-fe2026022616289

Cite this

Hyvarinen, T., Tilvis, J., Giudice, L., Tujula, I., Nylund, M., Ohtonen, S., Scoyni, F., Jantti, H., Virtanen, L., Pihlava, S., Kattelus, R., Skottman, H., Narkilahti, S., Airas, L., Malm, T., & Hagman, S. (2025). Microglia from patients with multiple sclerosis display a cell-autonomous immune activation state. Journal of Neuroinflammation, 22(1), Article 255. https://doi.org/10.1186/s12974-025-03575-4

@article{3c092d2f028b4992ba43cf898a7ee4c9,

title = "Microglia from patients with multiple sclerosis display a cell-autonomous immune activation state",

keywords = "Human induced pluripotent stem cells, Microglia, Multiple sclerosis, Neuroinflammation",

author = "Tanja Hyvarinen and Johanna Tilvis and Luca Giudice and Iisa Tujula and Marjo Nylund and Sohvi Ohtonen and Flavia Scoyni and Henna Jantti and Lassi Virtanen and Sara Pihlava and Roosa Kattelus and Heli Skottman and Susanna Narkilahti and Laura Airas and Tarja Malm and Sanna Hagman",

year = "2025",

month = oct,

day = "31",

doi = "10.1186/s12974-025-03575-4",

language = "English",

volume = "22",

journal = "Journal of Neuroinflammation",

issn = "1742-2094",

publisher = "Biomed central",

number = "1",

}

Hyvarinen, T, Tilvis, J, Giudice, L, Tujula, I, Nylund, M, Ohtonen, S, Scoyni, F, Jantti, H, Virtanen, L, Pihlava, S, Kattelus, R, Skottman, H, Narkilahti, S, Airas, L, Malm, T & Hagman, S 2025, 'Microglia from patients with multiple sclerosis display a cell-autonomous immune activation state', Journal of Neuroinflammation, vol. 22, no. 1, 255. https://doi.org/10.1186/s12974-025-03575-4

TY - JOUR

T1 - Microglia from patients with multiple sclerosis display a cell-autonomous immune activation state

AU - Hyvarinen, Tanja

AU - Tilvis, Johanna

AU - Giudice, Luca

AU - Tujula, Iisa

AU - Nylund, Marjo

AU - Ohtonen, Sohvi

AU - Scoyni, Flavia

AU - Jantti, Henna

AU - Virtanen, Lassi

AU - Pihlava, Sara

AU - Kattelus, Roosa

AU - Skottman, Heli

AU - Narkilahti, Susanna

AU - Airas, Laura

AU - Malm, Tarja

AU - Hagman, Sanna

PY - 2025/10/31

Y1 - 2025/10/31

KW - Human induced pluripotent stem cells

KW - Microglia

KW - Multiple sclerosis

KW - Neuroinflammation

UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=aboakademi&SrcAuth=WosAPI&KeyUT=WOS:001606912400001&DestLinkType=FullRecord&DestApp=WOS_CPL

U2 - 10.1186/s12974-025-03575-4

DO - 10.1186/s12974-025-03575-4

M3 - Article

C2 - 41174786

SN - 1742-2094

VL - 22

JO - Journal of Neuroinflammation

JF - Journal of Neuroinflammation

IS - 1

M1 - 255

ER -

Microglia from patients with multiple sclerosis display a cell-autonomous immune activation state

Keywords

Access to Document

Other files and links

Cite this