Abstract
In this review, we summarize the latest developments and give a perspective on future applications of mesoporous silica nanoparticles (MSNs) in regenerative medicine. MSNs constitute a flexible platform for controlled delivery of drugs and imaging agents in tissue engineering and stem cell therapy. We highlight the recent advances in applying MSNs for controlled drug delivery and stem cell tracking. We touch upon novel functions of MSNs in real time imaging of drug release and biological function, and as tools to control the chemical and mechanical environment of stem cells. We discuss the need for novel model systems for studying biofunctionality and biocompatibility of MSNs, and how the interdisciplinary activities within the field will advance biotechnology research.
| Original language | Undefined/Unknown |
|---|---|
| Pages (from-to) | 391–402 |
| Journal | Nanomedicine |
| Volume | 11 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2016 |
| MoE publication type | A2 Review article in a scientific journal |
Funding
The authors acknowledge funding agencies in Europe (FP7, MC-CIG, NanoEar), Finland (Academy of Finland, Sigrid Juselius Foundation, Åbo Akademi University, Cancer Society, and Germany Ulm University, Baden-Württemberg Stiftung, and DAAD and the Eindhoven University of technology who have supported the authors' strive so far to develop the MSN technology for biomedical applications. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.