Mesoporous silica nanoparticles in tissue engineering – a perspective

Jessica Rosenholm, Jixi Zhang, Mika Linden, Cecilia Sahlgren

Research output: Contribution to journalReview Article or Literature ReviewScientificpeer-review

51 Citations (Scopus)

Abstract

In this review, we summarize the latest developments and give a perspective on future applications of mesoporous silica nanoparticles (MSNs) in regenerative medicine. MSNs constitute a flexible platform for controlled delivery of drugs and imaging agents in tissue engineering and stem cell therapy. We highlight the recent advances in applying MSNs for controlled drug delivery and stem cell tracking. We touch upon novel functions of MSNs in real time imaging of drug release and biological function, and as tools to control the chemical and mechanical environment of stem cells. We discuss the need for novel model systems for studying biofunctionality and biocompatibility of MSNs, and how the interdisciplinary activities within the field will advance biotechnology research.
Original languageUndefined/Unknown
Pages (from-to)391–402
JournalNanomedicine
Volume11
Issue number4
DOIs
Publication statusPublished - 2016
MoE publication typeA2 Review article in a scientific journal

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