Mesoporous Silica Nanoparticles as Carriers for Biomolecules in Cancer Therapy

Berrin Küçüktürkmen, Jessica M. Rosenholm

Research output: Chapter in Book/Conference proceedingChapterScientificpeer-review

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Abstract

Mesoporous silica nanoparticles (MSNs) offer many advantageous properties for applications in the field of nanobiotechnology. Loading of small molecules into MSNs is straightforward and widely applied, but with the upswing of both research and commercial interest in biological drugs in recent years, also biomacromolecules have been loaded into MSNs for delivery purposes. MSNs possess many critical properties making them a promising and versatile carrier for biomacromolecular delivery. In this chapter, we review the effects of the various structural parameters of MSNs on the effective loading of biomacromolecular therapeutics, with focus on maintaining stability and drug delivery performance. We also emphasize recent studies involving the use of MSNs in the delivery of biomacromolecular drugs, especially for cancer treatment.
Original languageEnglish
Title of host publicationBio-Nanomedicine for Cancer Therapy
EditorsFlavia Fontana, Hélder A. Santos
Place of PublicationCham
PublisherSpringer International Publishing
Pages99-120
ISBN (Electronic)978-3-030-58174-9
ISBN (Print)978-3-030-58173-2
DOIs
Publication statusPublished - 2 Feb 2021
MoE publication typeA3 Part of a book or another research book

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1295
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Mesoporous silica nanoparticles
  • Biomolecules
  • Biological drugs
  • Biologics
  • Protein drugs
  • Stimuli-responsive drug release
  • Controlled drug release
  • Photodynamic therapy
  • Peptide delivery
  • Protein delivery
  • Gene delivery
  • Cancer immunotherapy
  • Co-delivery
  • Inorganic drug carriers
  • Macromolecular drug delivery
  • Drug delivery
  • Drug delivery systems
  • Biomacromolecules

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