Mesoporous silica material TUD-1 as a drug delivery system

T. Heikkilä, J. Salonen, J. Tuura, M. S. Hamdy, G. Mul, N. Kumar, T. Salmi, D. Yu Murzin, L. Laitinen, A. M. Kaukonen, J. Hirvonen, V. P. Lehto*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

177 Citations (Scopus)

Abstract

For the first time the feasibility of siliceous mesoporous material TUD-1 (Technische Universiteit Delft) for drug delivery was studied. Model drug, ibuprofen, was adsorbed into TUD-1 mesopores via a soaking procedure. Characterizations with nitrogen adsorption, XRD, TG, HPLC and DSC demonstrated the successful inclusion of ibuprofen into TUD-1 host. The amount of ibuprofen adsorbed into the nanoreservoir of TUD-1 material was higher than reported for other mesoporous silica drug carriers (drug/carrier 49.5 wt.%). Drug release studies in vitro (HBSS buffer pH 5.5) demonstrated a fast and unrestricted liberation of ibuprofen, with 96% released at 210 min of the dissolution assay. The drug dissolution profile of TUD-1 material with the random, foam-like three-dimensional mesopore network and high accessibility to the dissolution medium was found to be much faster (kinetic constant k = 10.7) and more diffusion based (release constant n = 0.64) compared to a mesoporous MCM-41 material with smaller, unidirectional mesopore channels (k = 4.7, n = 0.71). Also, the mesoporous carriers were found to significantly increase the dissolution rate of ibuprofen, when compared to the pure crystalline form of the drug (k = 0.6, n = 0.96). TUD-1 was constituted as a potential drug delivery device with fast release property, with prospective applications in the formulation of poorly soluble drug compounds.

Original languageEnglish
Pages (from-to)133-138
Number of pages6
JournalInternational Journal of Pharmaceutics
Volume331
Issue number1
DOIs
Publication statusPublished - 22 Feb 2007
MoE publication typeA1 Journal article-refereed

Keywords

  • Drug carrier
  • Drug delivery
  • Drug loading
  • Drug release
  • Mesoporous silica TUD-1

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