TY - JOUR
T1 - Mesoporous silica material TUD-1 as a drug delivery system
AU - Heikkilä, T.
AU - Salonen, J.
AU - Tuura, J.
AU - Hamdy, M. S.
AU - Mul, G.
AU - Kumar, N.
AU - Salmi, T.
AU - Murzin, D. Yu.
AU - Laitinen, L.
AU - Kaukonen, A. M.
AU - Hirvonen, J.
AU - Lehto, V.-P.
N1 - Funding Information:
The financial support from the Academy of Finland (grant no. 211048 and 202258) and the Finnish Academy of Science and Letters (Vilho, Yrjö and Kalle Väisälä Foundation) is acknowledged. In addition, the authors wish to thank LicPhil. M. Tenho, MSc. T. Limnell and Mr. J. Riikonen for their valuable scientific input to this work.
Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2007/2/22
Y1 - 2007/2/22
N2 - For the first time the feasibility of siliceous mesoporous material TUD-1 (Technische Universiteit Delft) for drug delivery was studied. Model drug, ibuprofen, was adsorbed into TUD-1 mesopores via a soaking procedure. Characterizations with nitrogen adsorption, XRD, TG, HPLC and DSC demonstrated the successful inclusion of ibuprofen into TUD-1 host. The amount of ibuprofen adsorbed into the nanoreservoir of TUD-1 material was higher than reported for other mesoporous silica drug carriers (drug/carrier 49.5 wt.%). Drug release studies in vitro (HBSS buffer pH 5.5) demonstrated a fast and unrestricted liberation of ibuprofen, with 96% released at 210 min of the dissolution assay. The drug dissolution profile of TUD-1 material with the random, foam-like three-dimensional mesopore network and high accessibility to the dissolution medium was found to be much faster (kinetic constant k = 10.7) and more diffusion based (release constant n = 0.64) compared to a mesoporous MCM-41 material with smaller, unidirectional mesopore channels (k = 4.7, n = 0.71). Also, the mesoporous carriers were found to significantly increase the dissolution rate of ibuprofen, when compared to the pure crystalline form of the drug (k = 0.6, n = 0.96). TUD-1 was constituted as a potential drug delivery device with fast release property, with prospective applications in the formulation of poorly soluble drug compounds.
AB - For the first time the feasibility of siliceous mesoporous material TUD-1 (Technische Universiteit Delft) for drug delivery was studied. Model drug, ibuprofen, was adsorbed into TUD-1 mesopores via a soaking procedure. Characterizations with nitrogen adsorption, XRD, TG, HPLC and DSC demonstrated the successful inclusion of ibuprofen into TUD-1 host. The amount of ibuprofen adsorbed into the nanoreservoir of TUD-1 material was higher than reported for other mesoporous silica drug carriers (drug/carrier 49.5 wt.%). Drug release studies in vitro (HBSS buffer pH 5.5) demonstrated a fast and unrestricted liberation of ibuprofen, with 96% released at 210 min of the dissolution assay. The drug dissolution profile of TUD-1 material with the random, foam-like three-dimensional mesopore network and high accessibility to the dissolution medium was found to be much faster (kinetic constant k = 10.7) and more diffusion based (release constant n = 0.64) compared to a mesoporous MCM-41 material with smaller, unidirectional mesopore channels (k = 4.7, n = 0.71). Also, the mesoporous carriers were found to significantly increase the dissolution rate of ibuprofen, when compared to the pure crystalline form of the drug (k = 0.6, n = 0.96). TUD-1 was constituted as a potential drug delivery device with fast release property, with prospective applications in the formulation of poorly soluble drug compounds.
KW - Drug carrier
KW - Drug delivery
KW - Drug loading
KW - Drug release
KW - Mesoporous silica TUD-1
UR - http://www.scopus.com/inward/record.url?scp=33846566855&partnerID=8YFLogxK
U2 - 10.1016/j.ijpharm.2006.09.019
DO - 10.1016/j.ijpharm.2006.09.019
M3 - Article
C2 - 17046183
AN - SCOPUS:33846566855
SN - 0378-5173
VL - 331
SP - 133
EP - 138
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
IS - 1
ER -