Mechanism of drug-induced neurotoxicity and its management

Rachna Gupta; Muktika Tekade; Nupur Vasdev; Tanisha Gupta; Bhakti Pawar; Kuldeep Kumar Bansal; Rakesh Kumar Tekade

doi:10.1016/B978-0-443-15840-7.00006-3

Mechanism of drug-induced neurotoxicity and its management

Rachna Gupta, Muktika Tekade, Nupur Vasdev, Tanisha Gupta, Bhakti Pawar, Kuldeep Kumar Bansal, Rakesh Kumar Tekade

Pharmacy

Research output: Chapter in Book/Conference proceeding › Chapter › Scientific › peer-review

3 Citations (Scopus)

Abstract

The drugs with neurotoxic potential are named neurotoxins and they bring changes in the structure and function of the central and peripheral nervous systems of the organisms. The neurotoxins can be antagonists or agonists with the receptors mediated toxicity to brain tissue. Neurotoxins can be antibiotics, chemotherapeutics, cardiovascular drugs, immunosuppressive agents, pesticides, alcohols, nanoparticles, and other agents. The neurotoxic potency of these drugs depends on their molecular structure and function. The knowledge of drug-induced neurotoxicity is necessary to enhance the protective approaches for neurodegenerative syndromes. This chapter focuses on the drug-induced neurotoxic effects manifested through various mechanisms and factors affecting toxicity. In addition, information on the preventive measures against neurotoxicity is also discussed.

Original language	English
Title of host publication	Essentials of Pharmatoxicology in Drug Research
Subtitle of host publication	Toxicity and Toxicodynamics
Publisher	Elsevier
Chapter	13
Pages	317-341
Number of pages	25
ISBN (Electronic)	9780443158407
DOIs	https://doi.org/10.1016/B978-0-443-15840-7.00006-3
Publication status	Published - 2023
MoE publication type	A3 Part of a book or another research book

Keywords

Nervous system
Neurologic diseases
Neurotoxicity
Neurotoxins
Prevention
Risk factors

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10.1016/B978-0-443-15840-7.00006-3

Cite this

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abstract = "The drugs with neurotoxic potential are named neurotoxins and they bring changes in the structure and function of the central and peripheral nervous systems of the organisms. The neurotoxins can be antagonists or agonists with the receptors mediated toxicity to brain tissue. Neurotoxins can be antibiotics, chemotherapeutics, cardiovascular drugs, immunosuppressive agents, pesticides, alcohols, nanoparticles, and other agents. The neurotoxic potency of these drugs depends on their molecular structure and function. The knowledge of drug-induced neurotoxicity is necessary to enhance the protective approaches for neurodegenerative syndromes. This chapter focuses on the drug-induced neurotoxic effects manifested through various mechanisms and factors affecting toxicity. In addition, information on the preventive measures against neurotoxicity is also discussed.",

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AU - Gupta, Rachna

AU - Tekade, Muktika

AU - Vasdev, Nupur

AU - Gupta, Tanisha

AU - Pawar, Bhakti

AU - Bansal, Kuldeep Kumar

AU - Tekade, Rakesh Kumar

PY - 2023

Y1 - 2023

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KW - Neurologic diseases

KW - Neurotoxicity

KW - Neurotoxins

KW - Prevention

KW - Risk factors

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BT - Essentials of Pharmatoxicology in Drug Research

PB - Elsevier

ER -

Mechanism of drug-induced neurotoxicity and its management

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Keywords

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