Abstract
Samples of mussels and flounders from the Baltic Sea were analysed for nodularin content on two different LC-MS instruments (triple quadrupole and ion trap). The triple quadrupole instrument was well suited for the quantitative analysis. The limit of detection in the selected ion recording mode was 5 pg and in the multiple reactant monitoring mode 500 pg on column for extracts of Nodularia spumigena. The fragmentation patterns of nodularin-R and desmethylnodularin-R were recorded and shown to be similar to those of microcystins. LC-MS proved to be an excellent tool for the analyses of cyanobacterial hepatotoxins in complex matrices.
| Original language | English |
|---|---|
| Pages (from-to) | 243-253 |
| Number of pages | 11 |
| Journal | Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences |
| Volume | 784 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 5 Feb 2003 |
| MoE publication type | A1 Journal article-refereed |
Funding
We wish to thank the Academy of Finland for financial support (RC for Natural Sciences and Engineering, project 47664 of J.M. and K.K., and RC for Biosciences and Environment, project 48019 of V.S.). K.K. also acknowledges the support from the National Graduate School of Informational and Structural Biology and the Magnus Ehrnrooth Foundation.
Keywords
- Desmethylnodularin
- Flounder
- Mussel
- Nodularin