Mass spectrometric detection of nodularin and desmethylnodularin in mussels and flounders

Krister Karlsson, Vesa Sipiä, Harri Kankaanpää, Jussi Meriluoto*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

54 Citations (Scopus)


Samples of mussels and flounders from the Baltic Sea were analysed for nodularin content on two different LC-MS instruments (triple quadrupole and ion trap). The triple quadrupole instrument was well suited for the quantitative analysis. The limit of detection in the selected ion recording mode was 5 pg and in the multiple reactant monitoring mode 500 pg on column for extracts of Nodularia spumigena. The fragmentation patterns of nodularin-R and desmethylnodularin-R were recorded and shown to be similar to those of microcystins. LC-MS proved to be an excellent tool for the analyses of cyanobacterial hepatotoxins in complex matrices.

Original languageEnglish
Pages (from-to)243-253
Number of pages11
JournalJournal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
Issue number2
Publication statusPublished - 5 Feb 2003
MoE publication typeA1 Journal article-refereed


  • Desmethylnodularin
  • Flounder
  • Mussel
  • Nodularin


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