Mass spectrometric detection of nodularin and desmethylnodularin in mussels and flounders

Krister Karlsson; Vesa Sipiä; Harri Kankaanpää; Jussi Meriluoto

doi:10.1016/S1570-0232(02)00802-4

Mass spectrometric detection of nodularin and desmethylnodularin in mussels and flounders

Krister Karlsson, Vesa Sipiä, Harri Kankaanpää, Jussi Meriluoto^*

^*Corresponding author for this work

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Abstract

Samples of mussels and flounders from the Baltic Sea were analysed for nodularin content on two different LC-MS instruments (triple quadrupole and ion trap). The triple quadrupole instrument was well suited for the quantitative analysis. The limit of detection in the selected ion recording mode was 5 pg and in the multiple reactant monitoring mode 500 pg on column for extracts of Nodularia spumigena. The fragmentation patterns of nodularin-R and desmethylnodularin-R were recorded and shown to be similar to those of microcystins. LC-MS proved to be an excellent tool for the analyses of cyanobacterial hepatotoxins in complex matrices.

Original language	English
Pages (from-to)	243-253
Number of pages	11
Journal	Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
Volume	784
Issue number	2
DOIs	https://doi.org/10.1016/S1570-0232(02)00802-4
Publication status	Published - 5 Feb 2003
MoE publication type	A1 Journal article-refereed

Keywords

Desmethylnodularin
Flounder
Mussel
Nodularin

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10.1016/S1570-0232(02)00802-4

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title = "Mass spectrometric detection of nodularin and desmethylnodularin in mussels and flounders",

abstract = "Samples of mussels and flounders from the Baltic Sea were analysed for nodularin content on two different LC-MS instruments (triple quadrupole and ion trap). The triple quadrupole instrument was well suited for the quantitative analysis. The limit of detection in the selected ion recording mode was 5 pg and in the multiple reactant monitoring mode 500 pg on column for extracts of Nodularia spumigena. The fragmentation patterns of nodularin-R and desmethylnodularin-R were recorded and shown to be similar to those of microcystins. LC-MS proved to be an excellent tool for the analyses of cyanobacterial hepatotoxins in complex matrices.",

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author = "Krister Karlsson and Vesa Sipi{\"a} and Harri Kankaanp{\"a}{\"a} and Jussi Meriluoto",

note = "Funding Information: We wish to thank the Academy of Finland for financial support (RC for Natural Sciences and Engineering, project 47664 of J.M. and K.K., and RC for Biosciences and Environment, project 48019 of V.S.). K.K. also acknowledges the support from the National Graduate School of Informational and Structural Biology and the Magnus Ehrnrooth Foundation. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

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doi = "10.1016/S1570-0232(02)00802-4",

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Mass spectrometric detection of nodularin and desmethylnodularin in mussels and flounders. / Karlsson, Krister; Sipiä, Vesa; Kankaanpää, Harri et al.
In: Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, Vol. 784, No. 2, 05.02.2003, p. 243-253.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Mass spectrometric detection of nodularin and desmethylnodularin in mussels and flounders

AU - Karlsson, Krister

AU - Sipiä, Vesa

AU - Kankaanpää, Harri

AU - Meriluoto, Jussi

N1 - Funding Information: We wish to thank the Academy of Finland for financial support (RC for Natural Sciences and Engineering, project 47664 of J.M. and K.K., and RC for Biosciences and Environment, project 48019 of V.S.). K.K. also acknowledges the support from the National Graduate School of Informational and Structural Biology and the Magnus Ehrnrooth Foundation. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2003/2/5

Y1 - 2003/2/5

N2 - Samples of mussels and flounders from the Baltic Sea were analysed for nodularin content on two different LC-MS instruments (triple quadrupole and ion trap). The triple quadrupole instrument was well suited for the quantitative analysis. The limit of detection in the selected ion recording mode was 5 pg and in the multiple reactant monitoring mode 500 pg on column for extracts of Nodularia spumigena. The fragmentation patterns of nodularin-R and desmethylnodularin-R were recorded and shown to be similar to those of microcystins. LC-MS proved to be an excellent tool for the analyses of cyanobacterial hepatotoxins in complex matrices.

AB - Samples of mussels and flounders from the Baltic Sea were analysed for nodularin content on two different LC-MS instruments (triple quadrupole and ion trap). The triple quadrupole instrument was well suited for the quantitative analysis. The limit of detection in the selected ion recording mode was 5 pg and in the multiple reactant monitoring mode 500 pg on column for extracts of Nodularia spumigena. The fragmentation patterns of nodularin-R and desmethylnodularin-R were recorded and shown to be similar to those of microcystins. LC-MS proved to be an excellent tool for the analyses of cyanobacterial hepatotoxins in complex matrices.

KW - Desmethylnodularin

KW - Flounder

KW - Mussel

KW - Nodularin

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SN - 1570-0232

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JO - Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

JF - Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

IS - 2

ER -

Mass spectrometric detection of nodularin and desmethylnodularin in mussels and flounders

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Keywords

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