Mass spectrometric detection and quantification of nodularin-R in flounder livers

Krister Karlsson; Vesa Sipiä; Eberhard Krause; Jussi Meriluoto; Stephan Pflugmacher

doi:10.1002/tox.10126

Mass spectrometric detection and quantification of nodularin-R in flounder livers

Krister Karlsson^*, Vesa Sipiä, Eberhard Krause, Jussi Meriluoto, Stephan Pflugmacher

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

23 Citations (Scopus)

Abstract

Livers of flounders caught during August 1995 from the western Gulf of Finland and the Archipelago Sea were analyzed for nodularin-R (NODLN) by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and liquid chromatography-electrospray ionization-mass spectrometry (LC-MS). Results showed that NODLN was detected in samples by both MS techniques. NODLN content in samples varied between 0.082 and 0.637 μg g^-1 wet weight by LC-MS. Biotransformation products such as glutathione adduct were not found in the samples. The results showed that intact NODLN can be found in tissues after storage at -70°C for several years.

Original language	English
Pages (from-to)	284-288
Number of pages	5
Journal	Environmental Toxicology
Volume	18
Issue number	5
DOIs	https://doi.org/10.1002/tox.10126
Publication status	Published - 2003
MoE publication type	A1 Journal article-refereed

Keywords

Baltic Sea
Flounder
Liver
Mass spectrometry
Nodularin

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10.1002/tox.10126

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title = "Mass spectrometric detection and quantification of nodularin-R in flounder livers",

abstract = "Livers of flounders caught during August 1995 from the western Gulf of Finland and the Archipelago Sea were analyzed for nodularin-R (NODLN) by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and liquid chromatography-electrospray ionization-mass spectrometry (LC-MS). Results showed that NODLN was detected in samples by both MS techniques. NODLN content in samples varied between 0.082 and 0.637 μg g-1 wet weight by LC-MS. Biotransformation products such as glutathione adduct were not found in the samples. The results showed that intact NODLN can be found in tissues after storage at -70°C for several years.",

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T1 - Mass spectrometric detection and quantification of nodularin-R in flounder livers

AU - Karlsson, Krister

AU - Sipiä, Vesa

AU - Krause, Eberhard

AU - Meriluoto, Jussi

AU - Pflugmacher, Stephan

PY - 2003

Y1 - 2003

N2 - Livers of flounders caught during August 1995 from the western Gulf of Finland and the Archipelago Sea were analyzed for nodularin-R (NODLN) by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and liquid chromatography-electrospray ionization-mass spectrometry (LC-MS). Results showed that NODLN was detected in samples by both MS techniques. NODLN content in samples varied between 0.082 and 0.637 μg g-1 wet weight by LC-MS. Biotransformation products such as glutathione adduct were not found in the samples. The results showed that intact NODLN can be found in tissues after storage at -70°C for several years.

AB - Livers of flounders caught during August 1995 from the western Gulf of Finland and the Archipelago Sea were analyzed for nodularin-R (NODLN) by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and liquid chromatography-electrospray ionization-mass spectrometry (LC-MS). Results showed that NODLN was detected in samples by both MS techniques. NODLN content in samples varied between 0.082 and 0.637 μg g-1 wet weight by LC-MS. Biotransformation products such as glutathione adduct were not found in the samples. The results showed that intact NODLN can be found in tissues after storage at -70°C for several years.

KW - Baltic Sea

KW - Flounder

KW - Liver

KW - Mass spectrometry

KW - Nodularin

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SP - 284

EP - 288

JO - Environmental Toxicology

JF - Environmental Toxicology

IS - 5

ER -

Mass spectrometric detection and quantification of nodularin-R in flounder livers

Abstract

Keywords

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