Mass spectrometric detection and quantification of nodularin-R in flounder livers

Krister Karlsson*, Vesa Sipiä, Eberhard Krause, Jussi Meriluoto, Stephan Pflugmacher

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

20 Citations (Scopus)

Abstract

Livers of flounders caught during August 1995 from the western Gulf of Finland and the Archipelago Sea were analyzed for nodularin-R (NODLN) by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and liquid chromatography-electrospray ionization-mass spectrometry (LC-MS). Results showed that NODLN was detected in samples by both MS techniques. NODLN content in samples varied between 0.082 and 0.637 μg g-1 wet weight by LC-MS. Biotransformation products such as glutathione adduct were not found in the samples. The results showed that intact NODLN can be found in tissues after storage at -70°C for several years.

Original languageEnglish
Pages (from-to)284-288
Number of pages5
JournalEnvironmental Toxicology
Volume18
Issue number5
DOIs
Publication statusPublished - 2003
MoE publication typeA1 Journal article-refereed

Keywords

  • Baltic Sea
  • Flounder
  • Liver
  • Mass spectrometry
  • Nodularin

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