Luteapyrone, a novel ƴ-pyrone isolated from the filamentous fungus Metapochonia lutea.

Roman Labuda; Markus Bacher; Hannes Gratzl; Maria Doppler; Alexandra Parich; Mohammed Aufy; Rosa Lemmens-Gruber; Rainer Schuhmacher; Kathrin Rychli; Martin Wagner; Thomas Rosenau; Joseph Strauss; Christoph Schüller

doi:10.3390/molecules26216589

Luteapyrone, a novel ƴ-pyrone isolated from the filamentous fungus Metapochonia lutea.

Roman Labuda^*
, Markus Bacher
, Hannes Gratzl
, Maria Doppler
, Alexandra Parich
, Mohammed Aufy
, Rosa Lemmens-Gruber
, Rainer Schuhmacher
, Kathrin Rychli
, Martin Wagner
, Thomas Rosenau
, Joseph Strauss
, Christoph Schüller

^*Corresponding author for this work

FNT Common

Research output: Contribution to journal › Article › Scientific › peer-review

7 Citations (Scopus)

Abstract

In the process of screening for new bioactive microbial metabolites we found a novel ƴpyrone derivative for which we propose the trivial name luteapyrone, in a recently described microscopic filamentous fungus, Metapochonia lutea BiMM-F96/DF4. The compound was isolated from the culture extract of the fungus grown on modified yeast extract sucrose medium by means of flash chromatography followed by preparative HPLC. The chemical structure was elucidated by NMR and LC-MS. The new compound was found to be non-cytotoxic against three mammalian cell lines (HEK 263, KB-3.1 and Caco-2). Similarly, no antimicrobial activity was observed in tested microorganisms (gram positive and negative bacteria, yeast and fungi).

Original language	English
Article number	6589
Journal	Molecules
Volume	26
Issue number	21
DOIs	https://doi.org/10.3390/molecules26216589
Publication status	Published - 1 Nov 2021
MoE publication type	A1 Journal article-refereed

Funding

Funding: The research platform Bioactive Microbial Metabolites (BiMM) is supported by grants K3-G-2/026-2013 and COMBIS/ LS16005 funded by the Gesellschaft für Forschungsförderung Nie-derösterreich m.b.H.

Keywords

Actinopyrones
Fungal metabolites
Verticillium-like species
Verticipyrone

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10.3390/molecules26216589Licence: CC BY

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title = "Luteapyrone, a novel ƴ-pyrone isolated from the filamentous fungus Metapochonia lutea.",

abstract = "In the process of screening for new bioactive microbial metabolites we found a novel ƴpyrone derivative for which we propose the trivial name luteapyrone, in a recently described microscopic filamentous fungus, Metapochonia lutea BiMM-F96/DF4. The compound was isolated from the culture extract of the fungus grown on modified yeast extract sucrose medium by means of flash chromatography followed by preparative HPLC. The chemical structure was elucidated by NMR and LC-MS. The new compound was found to be non-cytotoxic against three mammalian cell lines (HEK 263, KB-3.1 and Caco-2). Similarly, no antimicrobial activity was observed in tested microorganisms (gram positive and negative bacteria, yeast and fungi).",

keywords = "Actinopyrones, Fungal metabolites, Verticillium-like species, Verticipyrone",

author = "Roman Labuda and Markus Bacher and Hannes Gratzl and Maria Doppler and Alexandra Parich and Mohammed Aufy and Rosa Lemmens-Gruber and Rainer Schuhmacher and Kathrin Rychli and Martin Wagner and Thomas Rosenau and Joseph Strauss and Christoph Sch{\"u}ller",

note = "Funding Information: Funding: The research platform Bioactive Microbial Metabolites (BiMM) is supported by grants K3-G-2/026-2013 and COMBIS/ LS16005 funded by the Gesellschaft f{\"u}r Forschungsf{\"o}rderung Nie-der{\"o}sterreich m.b.H. Publisher Copyright: {\textcopyright} 2021 Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = nov,

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doi = "10.3390/molecules26216589",

language = "English",

volume = "26",

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T1 - Luteapyrone, a novel ƴ-pyrone isolated from the filamentous fungus Metapochonia lutea.

AU - Labuda, Roman

AU - Bacher, Markus

AU - Gratzl, Hannes

AU - Doppler, Maria

AU - Parich, Alexandra

AU - Aufy, Mohammed

AU - Lemmens-Gruber, Rosa

AU - Schuhmacher, Rainer

AU - Rychli, Kathrin

AU - Wagner, Martin

AU - Rosenau, Thomas

AU - Strauss, Joseph

AU - Schüller, Christoph

N1 - Funding Information: Funding: The research platform Bioactive Microbial Metabolites (BiMM) is supported by grants K3-G-2/026-2013 and COMBIS/ LS16005 funded by the Gesellschaft für Forschungsförderung Nie-derösterreich m.b.H. Publisher Copyright: © 2021 Licensee MDPI, Basel, Switzerland.

PY - 2021/11/1

Y1 - 2021/11/1

N2 - In the process of screening for new bioactive microbial metabolites we found a novel ƴpyrone derivative for which we propose the trivial name luteapyrone, in a recently described microscopic filamentous fungus, Metapochonia lutea BiMM-F96/DF4. The compound was isolated from the culture extract of the fungus grown on modified yeast extract sucrose medium by means of flash chromatography followed by preparative HPLC. The chemical structure was elucidated by NMR and LC-MS. The new compound was found to be non-cytotoxic against three mammalian cell lines (HEK 263, KB-3.1 and Caco-2). Similarly, no antimicrobial activity was observed in tested microorganisms (gram positive and negative bacteria, yeast and fungi).

AB - In the process of screening for new bioactive microbial metabolites we found a novel ƴpyrone derivative for which we propose the trivial name luteapyrone, in a recently described microscopic filamentous fungus, Metapochonia lutea BiMM-F96/DF4. The compound was isolated from the culture extract of the fungus grown on modified yeast extract sucrose medium by means of flash chromatography followed by preparative HPLC. The chemical structure was elucidated by NMR and LC-MS. The new compound was found to be non-cytotoxic against three mammalian cell lines (HEK 263, KB-3.1 and Caco-2). Similarly, no antimicrobial activity was observed in tested microorganisms (gram positive and negative bacteria, yeast and fungi).

KW - Actinopyrones

KW - Fungal metabolites

KW - Verticillium-like species

KW - Verticipyrone

UR - https://www.scopus.com/pages/publications/85118412986

U2 - 10.3390/molecules26216589

DO - 10.3390/molecules26216589

M3 - Article

C2 - 34770997

AN - SCOPUS:85118412986

SN - 1420-3049

VL - 26

JO - Molecules

JF - Molecules

IS - 21

M1 - 6589

ER -

Luteapyrone, a novel ƴ-pyrone isolated from the filamentous fungus Metapochonia lutea.

Abstract

Funding

Keywords

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