Low kidney uptake of GLP-1R-targeting, beta cell-specific PET tracer, F-18-labeled [Nle(14),Lys(40)]exendin-4 analog, shows promise for clinical imaging

Kirsi Mikkola; Cheng-Bin Yim; Paula Lehtiniemi; Saila Kauhanen; Miikka Tarkia; Tuula Tolvanen; Pirjo Nuutila; Olof Solin

doi:10.1186/s13550-016-0243-2

Low kidney uptake of GLP-1R-targeting, beta cell-specific PET tracer, F-18-labeled [Nle(14),Lys(40)]exendin-4 analog, shows promise for clinical imaging

Kirsi Mikkola, Cheng-Bin Yim, Paula Lehtiniemi, Saila Kauhanen, Miikka Tarkia, Tuula Tolvanen, Pirjo Nuutila, Olof Solin

Turku PET Centre

Research output: Contribution to journal › Article › Scientific › peer-review

18 Citations (Scopus)

Abstract

Conclusions: [F-18] exendin-4 showed promise as a tracer for clinical imaging of pancreatic beta cells, due to its high specific uptake in native beta cells and its concomitant low kidney radioactivity uptake.

Original language	Undefined/Unknown
Pages (from-to)	–
Number of pages	11
Journal	EJNMMI Research
Volume	6
DOIs	https://doi.org/10.1186/s13550-016-0243-2
Publication status	Published - 2016
MoE publication type	A1 Journal article-refereed

Keywords

beta cell
Exendin
F-18
Pancreas
PET

Access to Document

10.1186/s13550-016-0243-2

https://ejnmmires.springeropen.com/articles/10.1186/s13550-016-0243-2

Cite this

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title = "Low kidney uptake of GLP-1R-targeting, beta cell-specific PET tracer, F-18-labeled [Nle(14),Lys(40)]exendin-4 analog, shows promise for clinical imaging",

abstract = "Conclusions: [F-18] exendin-4 showed promise as a tracer for clinical imaging of pancreatic beta cells, due to its high specific uptake in native beta cells and its concomitant low kidney radioactivity uptake.",

keywords = "beta cell, Exendin, F-18, Pancreas, PET, beta cell, Exendin, F-18, Pancreas, PET, beta cell, Exendin, F-18, Pancreas, PET",

author = "Kirsi Mikkola and Cheng-Bin Yim and Paula Lehtiniemi and Saila Kauhanen and Miikka Tarkia and Tuula Tolvanen and Pirjo Nuutila and Olof Solin",

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doi = "10.1186/s13550-016-0243-2",

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journal = "EJNMMI Research",

issn = "2191-219X",

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T1 - Low kidney uptake of GLP-1R-targeting, beta cell-specific PET tracer, F-18-labeled [Nle(14),Lys(40)]exendin-4 analog, shows promise for clinical imaging

AU - Mikkola, Kirsi

AU - Yim, Cheng-Bin

AU - Lehtiniemi, Paula

AU - Kauhanen, Saila

AU - Tarkia, Miikka

AU - Tolvanen, Tuula

AU - Nuutila, Pirjo

AU - Solin, Olof

PY - 2016

Y1 - 2016

N2 - Conclusions: [F-18] exendin-4 showed promise as a tracer for clinical imaging of pancreatic beta cells, due to its high specific uptake in native beta cells and its concomitant low kidney radioactivity uptake.

AB - Conclusions: [F-18] exendin-4 showed promise as a tracer for clinical imaging of pancreatic beta cells, due to its high specific uptake in native beta cells and its concomitant low kidney radioactivity uptake.

KW - beta cell

KW - Exendin

KW - F-18

KW - Pancreas

KW - PET

KW - beta cell

KW - Exendin

KW - F-18

KW - Pancreas

KW - PET

KW - beta cell

KW - Exendin

KW - F-18

KW - Pancreas

KW - PET

U2 - 10.1186/s13550-016-0243-2

DO - 10.1186/s13550-016-0243-2

M3 - Artikel

SN - 2191-219X

VL - 6

SP - –

JO - EJNMMI Research

JF - EJNMMI Research

ER -