Living hydrogel with blood derived elements for wound healing

Yuanyuan Jiang; Xiangyi Wu; Xiaoju Wang; Bin Kong; Jinglin Wang; Hongbo Zhang

doi:10.1016/j.mtbio.2025.102002

Living hydrogel with blood derived elements for wound healing

Yuanyuan Jiang, Xiangyi Wu, Xiaoju Wang, Bin Kong^*, Jinglin Wang^*, Hongbo Zhang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

2 Citations (Scopus)

Abstract

Blood plays a vital role in wound healing, as platelets (PLTs) initiate primary hemostasis and red blood cells (RBCs) continuously supply oxygen. Inspired by the intrinsic functions of RBCs and PLTs, we developed a living hydrogel incorporating RBCs, PLTs, and black phosphorus quantum dots (BP QDs) to accelerate wound healing. Owing to its three-dimensional (3D) pleated surface structure and excellent biocompatibility, the hydrogel exhibited enhanced cell seeding efficiency and provided effective support for both hemostasis and tissue regeneration. By leveraging the photo-responsive properties of BP QDs, the hydrogel acquired a controllable photothermal effect, enabling NIR-triggered oxygen release. Additionally, polymyxin was incorporated into the hydrogel matrix to endow the material with antibacterial properties. Benefiting from these combined features, the bioinspired living hydrogel significantly promoted wound repair in in vivo evaluations. Collectively, these findings highlight the potential of our bioinspired living hydrogel as a promising therapeutic strategy for enhanced wound healing.

Original language	English
Article number	102002
Journal	Materials Today Bio
Volume	33
DOIs	https://doi.org/10.1016/j.mtbio.2025.102002
Publication status	Published - Aug 2025
MoE publication type	A1 Journal article-refereed

Funding

This work was supported by the Research Fellow (Grant No.353146), Project (347897), Solution for Health Profile (336355), InFLAMES Flagship (337531) grants from Academy of Finland, Finland China Food and Health International Pilot Project funded by the Finnish Ministry of Education and Culture, the Guangdong Basic and Applied Basic Research Foundation (2024A1515010457), the Shenzhen Science and Technology Program (JCYJ20240813175800001), the Shenzhen Medical Research Fund (A2303017 and B2401006), the Shenzhen Science and Technology Program (JCYJ20240813175800001), the Jiangsu Provincial Science and Technology Special Fund for Outstanding Young Scholars (BK20230051), the Nanjing health science and technology development project for Distin-guished Young Scholars (JQX22003), Clinical research project of Children's Hospital of Nanjing Medical University (LCYJY202311), Youth Science Fund Cultivation Program of Children’ s Hospital of Nanjing Medical University (QNPY2024006), fundings for Clinical Trials from the Affiliated Drum Tower Hospital, and Medical School of Nanjing University (2021-LCYJ-PY-46). This study is part of the activities of the Åbo Akademi University Foundation (SÅA) funded Center of Excellence in Research "Materials-driven solutions for combating antimicrobial resistance (MADNESS)".

Keywords

Hydrogel
Oxygen
Platelet
Red blood cell
Wound healing

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10.1016/j.mtbio.2025.102002

Cite this

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title = "Living hydrogel with blood derived elements for wound healing",

abstract = "Blood plays a vital role in wound healing, as platelets (PLTs) initiate primary hemostasis and red blood cells (RBCs) continuously supply oxygen. Inspired by the intrinsic functions of RBCs and PLTs, we developed a living hydrogel incorporating RBCs, PLTs, and black phosphorus quantum dots (BP QDs) to accelerate wound healing. Owing to its three-dimensional (3D) pleated surface structure and excellent biocompatibility, the hydrogel exhibited enhanced cell seeding efficiency and provided effective support for both hemostasis and tissue regeneration. By leveraging the photo-responsive properties of BP QDs, the hydrogel acquired a controllable photothermal effect, enabling NIR-triggered oxygen release. Additionally, polymyxin was incorporated into the hydrogel matrix to endow the material with antibacterial properties. Benefiting from these combined features, the bioinspired living hydrogel significantly promoted wound repair in in vivo evaluations. Collectively, these findings highlight the potential of our bioinspired living hydrogel as a promising therapeutic strategy for enhanced wound healing.",

keywords = "Hydrogel, Oxygen, Platelet, Red blood cell, Wound healing",

author = "Yuanyuan Jiang and Xiangyi Wu and Xiaoju Wang and Bin Kong and Jinglin Wang and Hongbo Zhang",

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T1 - Living hydrogel with blood derived elements for wound healing

AU - Jiang, Yuanyuan

AU - Wu, Xiangyi

AU - Wang, Xiaoju

AU - Kong, Bin

AU - Wang, Jinglin

AU - Zhang, Hongbo

PY - 2025/8

Y1 - 2025/8

N2 - Blood plays a vital role in wound healing, as platelets (PLTs) initiate primary hemostasis and red blood cells (RBCs) continuously supply oxygen. Inspired by the intrinsic functions of RBCs and PLTs, we developed a living hydrogel incorporating RBCs, PLTs, and black phosphorus quantum dots (BP QDs) to accelerate wound healing. Owing to its three-dimensional (3D) pleated surface structure and excellent biocompatibility, the hydrogel exhibited enhanced cell seeding efficiency and provided effective support for both hemostasis and tissue regeneration. By leveraging the photo-responsive properties of BP QDs, the hydrogel acquired a controllable photothermal effect, enabling NIR-triggered oxygen release. Additionally, polymyxin was incorporated into the hydrogel matrix to endow the material with antibacterial properties. Benefiting from these combined features, the bioinspired living hydrogel significantly promoted wound repair in in vivo evaluations. Collectively, these findings highlight the potential of our bioinspired living hydrogel as a promising therapeutic strategy for enhanced wound healing.

AB - Blood plays a vital role in wound healing, as platelets (PLTs) initiate primary hemostasis and red blood cells (RBCs) continuously supply oxygen. Inspired by the intrinsic functions of RBCs and PLTs, we developed a living hydrogel incorporating RBCs, PLTs, and black phosphorus quantum dots (BP QDs) to accelerate wound healing. Owing to its three-dimensional (3D) pleated surface structure and excellent biocompatibility, the hydrogel exhibited enhanced cell seeding efficiency and provided effective support for both hemostasis and tissue regeneration. By leveraging the photo-responsive properties of BP QDs, the hydrogel acquired a controllable photothermal effect, enabling NIR-triggered oxygen release. Additionally, polymyxin was incorporated into the hydrogel matrix to endow the material with antibacterial properties. Benefiting from these combined features, the bioinspired living hydrogel significantly promoted wound repair in in vivo evaluations. Collectively, these findings highlight the potential of our bioinspired living hydrogel as a promising therapeutic strategy for enhanced wound healing.

KW - Hydrogel

KW - Oxygen

KW - Platelet

KW - Red blood cell

KW - Wound healing

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SN - 2590-0064

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JO - Materials Today Bio

JF - Materials Today Bio

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ER -

Living hydrogel with blood derived elements for wound healing

Abstract

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Keywords

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