Lipid-protein interplay and lateral organization in biomembranes

Thomas Nyholm

Research output: Contribution to journalArticleScientificpeer-review

34 Citations (Scopus)

Abstract

The distribution of lipids and membrane proteins within and between cellular membranes is carefully regulated. This sorting of lipids and proteins results in compositional differences between membrane compartments, bilayer leaflets, and lateral domains in the bilayer plane. The lateral organization of lipids and proteins has proven challenging to investigate, and the driving mechanisms remains unclear. Lipid self-organization has an essential role in the formation of lateral membrane structure, but the role of transmembrane proteins is not well known. This review focuses on how lateral lipid structure can affect the lateral distribution of proteins and how proteins could influence the organization of lipids in biomembranes.
Original languageUndefined/Unknown
Pages (from-to)48–55
JournalChemistry and Physics of Lipids
Volume189
Publication statusPublished - 2015
MoE publication typeA1 Journal article-refereed

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