Lignans 7-hydroxymatairesinol and 7-hydroxymatairesinol 2 exhibit anti-inflammatory activity in human aortic endothelial cells

Eliana Spilioti, Bjarne Holmbom, Athanasios G. Papavassiliou, Paraskevi Moutsatsou

    Research output: Contribution to journalArticleScientificpeer-review

    29 Citations (Scopus)


    Our results demonstrated that the lignans HMR and HMR2, dominant in cereals, such as in wheat, triticale, oat, barley, millet, corn bran, and in amaranth whole grain, exhibit stron anti-infammatory properties in endothelial cells, at least in part, through attenuation of nuclear factor-кB and extracellular regulated kinase phosphorylation.
    Original languageUndefined/Unknown
    Pages (from-to)749–759
    JournalMolecular Nutrition and Food Research
    Issue number4
    Publication statusPublished - 2014
    MoE publication typeA1 Journal article-refereed


    • Adhesion molecules
    • Atherosclerosis
    • Endothelial cells
    • 7-Hydoxymatairesinol
    • Lignans

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