Lignans 7-hydroxymatairesinol and 7-hydroxymatairesinol 2 exhibit anti-inflammatory activity in human aortic endothelial cells

Eliana Spilioti; Bjarne Holmbom; Athanasios G. Papavassiliou; Paraskevi Moutsatsou

doi:10.1002/nmfr.201300318

Lignans 7-hydroxymatairesinol and 7-hydroxymatairesinol 2 exhibit anti-inflammatory activity in human aortic endothelial cells

Eliana Spilioti, Bjarne Holmbom, Athanasios G. Papavassiliou, Paraskevi Moutsatsou

Research output: Contribution to journal › Article › Scientific › peer-review

30 Citations (Scopus)

Abstract

Our results demonstrated that the lignans HMR and HMR2, dominant in cereals, such as in wheat, triticale, oat, barley, millet, corn bran, and in amaranth whole grain, exhibit stron anti-infammatory properties in endothelial cells, at least in part, through attenuation of nuclear factor-кB and extracellular regulated kinase phosphorylation.

Original language	Undefined/Unknown
Pages (from-to)	749–759
Journal	Molecular Nutrition and Food Research
Volume	58
Issue number	4
DOIs	https://doi.org/10.1002/nmfr.201300318
Publication status	Published - 2014
MoE publication type	A1 Journal article-refereed

Keywords

Adhesion molecules
Atherosclerosis
Endothelial cells
7-Hydoxymatairesinol
Lignans

Access to Document

10.1002/nmfr.201300318

Cite this

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title = "Lignans 7-hydroxymatairesinol and 7-hydroxymatairesinol 2 exhibit anti-inflammatory activity in human aortic endothelial cells",

abstract = "Our results demonstrated that the lignans HMR and HMR2, dominant in cereals, such as in wheat, triticale, oat, barley, millet, corn bran, and in amaranth whole grain, exhibit stron anti-infammatory properties in endothelial cells, at least in part, through attenuation of nuclear factor-кB and extracellular regulated kinase phosphorylation.",

keywords = "Adhesion molecules, Atherosclerosis, Endothelial cells, 7-Hydoxymatairesinol, Lignans, Adhesion molecules, Atherosclerosis, Endothelial cells, 7-Hydoxymatairesinol, Lignans, Adhesion molecules, Atherosclerosis, Endothelial cells, 7-Hydoxymatairesinol, Lignans",

author = "Eliana Spilioti and Bjarne Holmbom and Papavassiliou, {Athanasios G.} and Paraskevi Moutsatsou",

year = "2014",

doi = "10.1002/nmfr.201300318",

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pages = "749–759",

journal = "Molecular Nutrition and Food Research",

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T1 - Lignans 7-hydroxymatairesinol and 7-hydroxymatairesinol 2 exhibit anti-inflammatory activity in human aortic endothelial cells

AU - Spilioti, Eliana

AU - Holmbom, Bjarne

AU - Papavassiliou, Athanasios G.

AU - Moutsatsou, Paraskevi

PY - 2014

Y1 - 2014

N2 - Our results demonstrated that the lignans HMR and HMR2, dominant in cereals, such as in wheat, triticale, oat, barley, millet, corn bran, and in amaranth whole grain, exhibit stron anti-infammatory properties in endothelial cells, at least in part, through attenuation of nuclear factor-кB and extracellular regulated kinase phosphorylation.

AB - Our results demonstrated that the lignans HMR and HMR2, dominant in cereals, such as in wheat, triticale, oat, barley, millet, corn bran, and in amaranth whole grain, exhibit stron anti-infammatory properties in endothelial cells, at least in part, through attenuation of nuclear factor-кB and extracellular regulated kinase phosphorylation.

KW - Adhesion molecules

KW - Atherosclerosis

KW - Endothelial cells

KW - 7-Hydoxymatairesinol

KW - Lignans

KW - Adhesion molecules

KW - Atherosclerosis

KW - Endothelial cells

KW - 7-Hydoxymatairesinol

KW - Lignans

KW - Adhesion molecules

KW - Atherosclerosis

KW - Endothelial cells

KW - 7-Hydoxymatairesinol

KW - Lignans

U2 - 10.1002/nmfr.201300318

DO - 10.1002/nmfr.201300318

M3 - Artikel

SN - 1613-4125

VL - 58

SP - 749

EP - 759

JO - Molecular Nutrition and Food Research

JF - Molecular Nutrition and Food Research

IS - 4

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