Isoindolinone Synthesis via One-Pot Type Transition Metal Catalyzed C−C Bond Forming Reactions

Risto Savela*, Carolina Méndez-Gálvez

*Corresponding author for this work

Research output: Contribution to journalReview Article or Literature Reviewpeer-review

1 Citation (Scopus)

Abstract

Isoindolinone structure is an important privileged scaffold found in a large variety of naturally occurring as well as synthetic, biologically and pharmaceutically active compounds. Owing to its crucial role in a number of applications, the synthetic methodologies for accessing this heterocyclic skeleton have received significant attention during the past decade. In general, the synthetic strategies can be divided into two categories: First, direct utilization of phthalimides or phthalimidines as starting materials for the synthesis of isoindolinones; and second, construction of the lactam and/or aromatic rings by different catalytic methods, including C−H activation, cross-coupling, carbonylation, condensation, addition and formal cycloaddition reactions. Especially in the last mentioned, utilization of transition metal catalysts provides access to a broad range of substituted isoindolinones. Herein, the recent advances (2010–2020) in transition metal catalyzed synthetic methodologies via formation of new C−C bonds for isoindolinones are reviewed.

Original languageEnglish
Pages (from-to)5344-5378
JournalChemistry - A European Journal
Volume27
Issue number17
DOIs
Publication statusAccepted/In press - 15 Oct 2020
MoE publication typeA2 Review article in a scientific journal

Keywords

  • catalysis
  • heterocycles
  • isoindolinone
  • synthesis
  • transition metals

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