Iron-Catalyzed Arylation of Aromatic Ketones and Aldehydes Mediated by Organosilanes

Risto Savela, Marcin Majewski, Reko Leino

    Research output: Contribution to journalArticleScientificpeer-review

    14 Citations (Scopus)


    A simple and efficient iron-catalyzed method for arylation of aromatic carbonyl compounds is reported. The use of 4% FeCl3 or Fe(acac)(3) as the catalyst, in combination with a slight excess of chlorotrimethylsilane and triethylsilane, chlorination of benzylic ketones and aldehydes with subsequent Friedel-Crafts alkylation of arenes is achieved. Although the method is limited by the general constraints associated with Friedel-Crafts alkylation reactions, robust applications for the synthesis of pharmaceutical intermediates and so on can be envisioned.
    Original languageUndefined/Unknown
    Pages (from-to)4137–4147
    Number of pages11
    JournalEuropean Journal of Organic Chemistry
    Issue number19
    Publication statusPublished - 2014
    MoE publication typeA1 Journal article-refereed


    • Homogeneous catalysis
    • Iron
    • Silanes
    • Synthetic methods

    Cite this