Ionic liquids affect the adsorption of liposomes onto cationic polyelectrolyte coated silica evidenced by quartz crystal microbalance

Filip Duša, Suvi Katriina Ruokonen, Ján Petrovaj, Tapani Viitala*, Susanne K. Wiedmer

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

10 Citations (Scopus)

Abstract

The worldwide use of ionic liquids (ILs) is steadily increasing, and even though they are often referred to as "green solvents" they have been reported to be toxic, especially toward aquatic organisms. In this work, we thoroughly study two phosphonium ILs; octyltributylphosphonium chloride ([P8444]Cl) and tributyl(tetradecyl)phosphonium chloride ([P14444]Cl). Firstly, the critical micelle concentrations (CMCs) of the ILs were determined with fluorescence spectroscopy and the optical pendant drop method in order to gain an understanding of the aggregation behavior of the ILs. Secondly, a biomimicking system of negatively charged unilamellar liposomes was used in order to study the effect of the ILs on biomembranes. Changes in the mechanical properties of adsorbed liposomes were determined by quartz crystal microbalance (QCM) measurements with silica coated quartz crystal sensors featuring a polycation layer. The results confirmed that both ILs were able to incorporate and alter the biomembrane structure. The membrane disrupting effect was emphasized with an increasing concentration and alkyl chain length of the ILs. In the extreme case, the phospholipid membrane integrity was completely compromised.

Original languageEnglish
Pages (from-to)496-505
Number of pages10
JournalColloids and Surfaces B: Biointerfaces
Volume136
DOIs
Publication statusPublished - 1 Dec 2015
Externally publishedYes
MoE publication typeA1 Journal article-refereed

Keywords

  • Critical micelle concentration
  • Ionic liquids
  • Liposomes
  • Polybrene
  • Quartz crystal microbalance
  • Toxicity

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