Application of magnesium selective electrodes to magnesium ion determination in biomedical samples has been introduced to analytical chemistry since 1990-ies. Using ion selective electrode, the ionized magnesium concentration is determined. Until this time, mainly concentration of total magnesium was determined. In this work, the importance of magnesium and its role in the human organism is shortly presented. Then, we present basics of ion selective electrodes and their application in clinical analyzers. We show exemplary applications of ionized and total magnesium concentration determination in clinical samples, such as blood serum or plasma and erythrocytes, in healthy people and in patients with various diseases. In every case, the ionized magnesium concentration in erythrocytes appears to be the most sensitive indicator of hypomagnesemia that is the pathophysiologically lowered magnesium level in organism. The knowledge of this parameter allows physicians for better diagnosis of magnesium status in human organism.
|Publication status||Published - 2015|
|MoE publication type||A1 Journal article-refereed|
- Magnesium selective electrodes
- magnesium speciation
- clinical analyzers
- Magnesium in human