Interplay between mammalian heat shock factors 1 and 2 in physiology and pathology

Research output: Contribution to journalReview Article or Literature Reviewpeer-review

10 Citations (Scopus)
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Abstract

The heat-shock factors (HSFs) belong to an evolutionary conserved family of transcription factors that were discovered already over 30 years ago. The HSFs have been shown to a have a broad repertoire of target genes, and they also have crucial functions during normal development. Importantly, HSFs have been linked to several disease states, such as neurodegenerative disorders and cancer, highlighting their importance in physiology and pathology. However, it is still unclear how HSFs are regulated and how they choose their specific target genes under different conditions. Posttranslational modifications and interplay among the HSF family members have been shown to be key regulatory mechanisms for these transcription factors. In this review, we focus on the mammalian HSF1 and HSF2, including their interplay, and provide an updated overview of the advances in understanding how HSFs are regulated and how they function in multiple processes of development, aging, and disease. We also discuss HSFs as therapeutic targets, especially the recently reported HSF1 inhibitors.

Original languageEnglish
Pages (from-to)7710-7725
Number of pages16
JournalFEBS Journal
Volume289
Issue number24
DOIs
Publication statusPublished - Dec 2022
MoE publication typeA2 Review article in a scientific journal

Keywords

  • Animals
  • Heat-Shock Proteins/genetics
  • Transcription Factors/genetics
  • Heat-Shock Response/genetics
  • Protein Processing, Post-Translational
  • Heat Shock Transcription Factors/genetics
  • Mammals/genetics

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