Intermediate filament dynamics

John Eriksson, P Opal, RD Goldman

    Research output: Contribution to journalReview Article or Literature Reviewpeer-review

    125 Citations (Scopus)

    Abstract

    The view of intermediate filaments as static cytoskeletal elements is changing. Studies of exogenous intermediate filament proteins, either microinjected or expressed from transfected genes, have demonstrated that a continuous incorporation of subunits into the polymerized filaments is taking place. This incorporation appears to be required for maintaining normal cytoplasmic networks of intermediate filaments. At the post-translational level, phosphorylation is an important factor in regulating dynamic aspects of intermediate filament organization and structure.
    Original languageUndefined/Unknown
    Pages (from-to)99–104
    JournalCurrent Opinion in Cell Biology
    Volume4
    Issue number1
    Publication statusPublished - 1992
    MoE publication typeA2 Review article in a scientific journal

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