Inkjet printing of drug substances and use of porous substrates-towards individualized dosing

Niklas Sandler*, Anni Määttänen, Petri Ihalainen, Leif Kronberg, Axel Meierjohann, Tapani Viitala, Jouko Peltonen

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

175 Citations (Scopus)


Medicines are most often oral solid dosage forms made into tablets or capsules, and there is little room for individualized doses. The drug substance and additives are processed through multiple production phases, including complex powder handling steps. In drug manufacturing, the control of the solid-state properties of active pharmaceutical ingredient (API) is essential and it offers opportunities for enhancement of drug delivery systems. In this context, inkjet printing technologies have emerged over the last decades in pharmaceutical and biological applications and offer solutions for controlling material and product characteristics with high precision. Here we report the concept of conventional inkjet printing technology to produce printable pharmaceutical dosage forms on porous substrates. Data are shown to demonstrate inkjet printing of APIs into paper substrates, and how the model drug substances (paracetamol, theophylline, and caffeine) are penetrating the porous substrates used. The method enables controlling not only the deposition but also the crystallization of the drug substances. We anticipate that the inkjet printing approach has immense potential in making sophisticated drug delivery systems by use of porous substrates in the future. For example, it may offer new perspectives for solving problems around poorly soluble drugs and dosing low-dose medicines accurately. Furthermore, with the advent of genetic mapping of humans, controlled inkjet dosing can bring solutions to fabricate on-demand individualized medicines for patients.

Original languageEnglish
Pages (from-to)3386-3395
Number of pages10
JournalJournal of Pharmaceutical Sciences
Issue number8
Publication statusPublished - Aug 2011
MoE publication typeA1 Journal article-refereed


  • Crystallization
  • Drug delivery systems
  • Drug manufacturing
  • Individualized drug theraphy
  • Inkjet printing
  • Paper substrates
  • Physical characterization
  • Surface chemistry


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