Projects per year
Abstract
The mechanical properties of polylactide stereocomplexes (PLA SC) have been primarily studied through tensile testing, with inconsistent results, and the compressive properties of PLA SC compared to homocrystalline or amorphous PLA remain poorly understood. In this study, we coated porous bioactive glass 13–93 scaffolds with amorphous, homocrystalline, or stereocomplex PLA to investigate their mechanical and degradation properties before and after immersion in simulated body fluid. The glass scaffolds had interconnected pores and an average porosity of 76%. The PLA coatings, which were 10–100 μm thick and approximately 3% of the glass scaffold mass, covered the glass to a large extent. The compressive strength and toughness of all PLA-coated scaffolds were significantly higher than those of uncoated scaffolds, with approximately a fourfold increase before immersion and a twofold increase after immersion. The compressive strength and toughness of PLA SC-coated scaffolds were similar to those of scaffolds with homocrystalline PLA coating, and significantly higher than for scaffolds with amorphous PLA coating. All PLA coatings moderated the initial pH increase caused by the glass, which could benefit surrounding cells and bone tissue in vivo after implantation.
| Original language | English |
|---|---|
| Article number | e35328 |
| Journal | Journal of Biomedical Materials Research Part B: Applied Biomaterials |
| Volume | 112 |
| Issue number | 1 |
| Early online date | 2023 |
| DOIs | |
| Publication status | Published - Jan 2024 |
| MoE publication type | A1 Journal article-refereed |
Funding
The authors would like to thank Sara Kiran for her work on the foam replication method to produce glass scaffolds. We would also like to thank Dr. Tiina Saloranta‐Simell for assistance with freeze drying, Jarl Hemming with the GPC measurements and Linus Silvander for the SEM analyses. Peter Uppstu is grateful for financial support from The Finnish Foundation of Technology Promotion, The Swedish Cultural Foundation in Finland, and the Åbo Akademi University Foundation.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Fingerprint
Dive into the research topics of 'Influence of polylactide coating stereochemistry on mechanical and in vitro degradation properties of porous bioactive glass scaffolds for bone regeneration'. Together they form a unique fingerprint.Projects
- 1 Active
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MADNESS: Centre of Excellence in Materials-driven solutions for combatting antimicrobial resistance
Rosenholm, J. (Principal Investigator), Porres Paltor, I. (Co-Principal Investigator), Bansal, K. (Coordinator), Lafond, S. (Co-Principal Investigator), Uppstu, P. (Co-Principal Investigator), Viitala, T. (Co-Principal Investigator), Wang, X. (Co-Principal Investigator), Wilen, C.-E. (Co-Principal Investigator), Xu, C. (Co-Principal Investigator), Zhang, H. (Co-Principal Investigator), Lu, Z. (Co-Investigator), Verma, J. (Co-Investigator), Kumar, V. (Co-Investigator), Frejborg, F. (Co-Investigator), Wang, S. (Co-Investigator), Ran, M. (Co-Investigator), Ma, X. (Co-Investigator), Yang, W. (Co-Investigator), Liang, S. (Co-Investigator), Zhang, Y. (Co-Investigator), Fan, L. (Co-Investigator), Chen, Y. (Co-Investigator), Wang, L. (Co-Investigator), Zhuang, P. (Co-Investigator), Rajan Prakash, D. (Co-Investigator), Howaili, F. (Co-Investigator), Gulshan, R. (Co-Investigator), Yadav, D. (Co-Investigator), Pathak, C. (Co-Investigator), Mustafa, R. (Co-Investigator), DarzianRostami, L. (Co-Investigator), Jafari Dargahlou, M. (Co-Investigator), Nygård, A. (Co-Investigator), Samrat, S. R. (Co-Investigator), Rexha, H. (Co-Investigator), Shiralizadeh Dezfuli, A. (Co-Investigator), Rahman Samrat, S. (Co-Investigator), Kohoolat, G. (Co-Investigator), Rezaeipour, Y. (Co-Investigator), Yadav, D. (Co-Investigator), Xia, Q. (Co-Investigator), Jafari Dargahlou, M. (Co-Investigator), Yang, W. (Co-Investigator) & Bayandori, M. (Co-Investigator)
01/01/24 → 31/12/28
Project: Foundation
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