Abstract
The influence of mass transfer limitations on the enantio- and regioselectivity in hydrogenation of 1-phenyl-1,2-propanedione was studied. Gas-liquid mass transfer limitation as well as liquid-solid mass transfer limitation did not influence the enantio- and regioselectivity of the reaction, compared to the performance of the system under kinetic control. Under various regimes, the enantiomeric excess of the (R)-1-hydroxy-1-phenylpropanone was about 55% and regioselectivity remained at about 10, which makes process scale-up with respect to enantio- and regioselectivity straightforward.
| Original language | English |
|---|---|
| Pages (from-to) | 189-193 |
| Number of pages | 5 |
| Journal | Catalysis Today |
| Volume | 79-80 |
| DOIs | |
| Publication status | Published - 30 Apr 2003 |
| MoE publication type | A4 Article in a conference publication |
| Event | Catalysis in Multiphase Reactors - Naples, Italy Duration: 29 May 2000 → 29 May 2000 |
Funding
This work is part of the activities at the Åbo Akademi Process Chemistry Group within the Finnish Centre of Excellence Programme (2000–2005) by the Academy of Finland. Financial support from Finnish Graduate School in Chemical Engineering (GSCE) is gratefully acknowledged.
Keywords
- 1-Phenyl-1,2-propanedione
- Mass transfer
- Pt catalysts