Increase in serum Interleukin-10 does not alleviate pro-inflammatory MCP-1 production in obese pregnancies

Lauri Polari, Himanshu Kumar, Samuli Rautava, Seppo Salminen, Erika Isolauri

Research output: Contribution to journalArticleScientificpeer-review

10 Citations (Scopus)


Maternal cytokine profiles during pregnancy are characterized by significant deviations, varying substantially between gestational time points and tissues. Obesity, in turn, is linked with low-grade inflammation in adipose tissue and increased concentrations of systemic inflammatory mediators. However, the balance of pro- and anti-inflammatory cytokines in obese pregnancy has remained elusive. In view of the demonstrations that the obesity is a global epidemic in the population at reproductive age with a strong intergenerational impact, we investigated the relation of gestational immune adaptations and obesity-induced inflammation. We found a significant decrease in systemic IL-1β and MCP-1 concentration from 1st to 3rd trimester of pregnancy while IL-10 concentration increased, respectively. However, in obese pregnancies this reduction of pro-inflammatory mediators was not detected. This may constitute an additional risk factor in obese pregnancies in which the concentration of MCP-1 is already upregulated compared to normal weight mothers.

Original languageEnglish
Pages (from-to)67-70
Number of pages4
Publication statusPublished - 2018
Externally publishedYes
MoE publication typeA1 Journal article-refereed


  • Adipose Tissue/immunology
  • Adult
  • Body Mass Index
  • Chemokine CCL2/blood
  • Female
  • Humans
  • Inflammation
  • Interleukin-10/blood
  • Interleukin-1beta/blood
  • Obesity/blood
  • Pregnancy
  • Prospective Studies
  • Randomized Controlled Trials as Topic


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