Abstract
Maternal cytokine profiles during pregnancy are characterized by significant deviations, varying substantially between gestational time points and tissues. Obesity, in turn, is linked with low-grade inflammation in adipose tissue and increased concentrations of systemic inflammatory mediators. However, the balance of pro- and anti-inflammatory cytokines in obese pregnancy has remained elusive. In view of the demonstrations that the obesity is a global epidemic in the population at reproductive age with a strong intergenerational impact, we investigated the relation of gestational immune adaptations and obesity-induced inflammation. We found a significant decrease in systemic IL-1β and MCP-1 concentration from 1st to 3rd trimester of pregnancy while IL-10 concentration increased, respectively. However, in obese pregnancies this reduction of pro-inflammatory mediators was not detected. This may constitute an additional risk factor in obese pregnancies in which the concentration of MCP-1 is already upregulated compared to normal weight mothers.
| Original language | English |
|---|---|
| Pages (from-to) | 67-70 |
| Number of pages | 4 |
| Journal | Cytokine |
| Volume | 108 |
| DOIs | |
| Publication status | Published - 2018 |
| Externally published | Yes |
| MoE publication type | A1 Journal article-refereed |
Keywords
- Adipose Tissue/immunology
- Adult
- Body Mass Index
- Chemokine CCL2/blood
- Female
- Humans
- Inflammation
- Interleukin-10/blood
- Interleukin-1beta/blood
- Obesity/blood
- Pregnancy
- Prospective Studies
- Randomized Controlled Trials as Topic