TY - JOUR
T1 - In vitro dissolution and characterization of flame-sprayed bioactive glass microspheres S53P4 and 13-93
AU - Sinitsyna, Polina
AU - Karlström, Oskar
AU - Sevonius, Christoffer
AU - Hupa, Leena
N1 - Funding Information:
This work was supported by the Graduate School of Chemical Engineering (GSCE) at Åbo Akademi University and the Academy of Finland (project no. 321598). This work was a part of the Business Finland project Biobased Smart Materials at Biomaterials Interface (project no. 8823/31/2019).
Publisher Copyright:
© 2022
PY - 2022
Y1 - 2022
N2 - Microspheres based on the bioactive glass S53P4 were successfully produced through flame-spraying. Glass 13–93 microspheres were utilised as a reference composition with a known behaviour in flame spheroidisation. Bioactive glass microspheres (BGMs) enable a range of advantages compared to conventional irregular-shaped particles. The produced BGMs in size ranges of 45–90 and 90–125 µm were characterised by DTA, SEM/EDXA, FTIR, and XRD. Dynamic dissolution experiments were carried out using TRIS buffer and SBF (pH 7.4) for 72 h. The ion concentrations in the solutions were measured using ICP-OES. The in vitro bioactivity results indicated that the hydroxyapatite (HA) layer was thicker for the larger spheres after dissolution in SBF. According to the SEM-EDXA results, the S53P4 spheres showed a more rapid formation of the hydroxyapatite layer than the reference 13–93. The thermal and in vitro properties of the BGMs were similar to the particles of the parent glasses. The results suggest that microspheres based on S53P4 bioactive glass have an excellent potential for future clinical applications.
AB - Microspheres based on the bioactive glass S53P4 were successfully produced through flame-spraying. Glass 13–93 microspheres were utilised as a reference composition with a known behaviour in flame spheroidisation. Bioactive glass microspheres (BGMs) enable a range of advantages compared to conventional irregular-shaped particles. The produced BGMs in size ranges of 45–90 and 90–125 µm were characterised by DTA, SEM/EDXA, FTIR, and XRD. Dynamic dissolution experiments were carried out using TRIS buffer and SBF (pH 7.4) for 72 h. The ion concentrations in the solutions were measured using ICP-OES. The in vitro bioactivity results indicated that the hydroxyapatite (HA) layer was thicker for the larger spheres after dissolution in SBF. According to the SEM-EDXA results, the S53P4 spheres showed a more rapid formation of the hydroxyapatite layer than the reference 13–93. The thermal and in vitro properties of the BGMs were similar to the particles of the parent glasses. The results suggest that microspheres based on S53P4 bioactive glass have an excellent potential for future clinical applications.
KW - Bioactive glass microspheres
KW - Dynamic dissolution
KW - In vitro bioactivity
KW - Ion release
KW - S53P4, Flame-spraying
UR - http://www.scopus.com/inward/record.url?scp=85131828302&partnerID=8YFLogxK
U2 - 10.1016/j.jnoncrysol.2022.121736
DO - 10.1016/j.jnoncrysol.2022.121736
M3 - Article
AN - SCOPUS:85131828302
SN - 0022-3093
VL - 591
JO - Journal of Non-Crystalline Solids
JF - Journal of Non-Crystalline Solids
M1 - 121736
ER -