In vitro behaviour of three biocompatible glasses in composite implants

L Varila, T Lehtonen, J Tuominen, Mikko Hupa, Leena Hupa

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    Poly(l,dl-lactide) composites containing filler particles of bioactive glasses 45S5 and S53P4 were compared with a composite containing a slowly dissolving glass S68. The in vitro reactivity of the composites was studied in simulated body fluid, Tris-buffered solution, and phosphate buffered saline. The high processing temperature induced thermal degradation giving cavities in the composites containing 45S5 and S53P4, while good adhesion of S68 to the polymer was observed. The cavities partly affected the in vitro reactivity of the composites. The degradation of the composites containing the bioactive glasses was faster in phosphate buffered saline than in the two other solutions. Hydroxyapatite precipitation suggesting bone tissue bonding capability was observed on these two composites in all three solutions. The slower dissolution of S68 glass particles and the limited hydroxyapatite precipitation suggested that this glass has potential as a reinforcing composition with the capability to guide bone tissue growth in biodegradable polymer composites.
    Original languageUndefined/Unknown
    Pages (from-to)2425–2435
    Number of pages11
    JournalJournal of Materials Science: Materials in Medicine
    Issue number10
    Publication statusPublished - 2012
    MoE publication typeA1 Journal article-refereed

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