In Situ: Microbial Aerodynamic Microneedles for Targeted Drug Delivery Systems

Chenyu Zong; Fei Wang; Wenguo Cui

doi:10.34133/research.0775

In Situ: Microbial Aerodynamic Microneedles for Targeted Drug Delivery Systems

Chenyu Zong
, Fei Wang^*
, Wenguo Cui^*

^*Corresponding author for this work

Research output: Contribution to journal › Review Article or Literature Review

2 Citations (Scopus)

Abstract

In situ microbial aerodynamic microneedles (MM-MNs) represent an autonomous transdermal drug delivery platform that utilizes the gas generated by microbial metabolism (e.g., H₂, NO, and H₂S) to propel drugs into deep tissues, surpassing the penetration limits of traditional microneedles reliant on external stimuli (heat/light/mechanical force). By leveraging controlled microbial metabolism, MM-MNs enable energy-independent, spatiotemporally precise delivery with enhanced targeting and bioavailability. Gas-driven propulsion combines with bioactive gas functions (e.g., NO-induced vasodilation and H₂S-mediated anti-inflammation) to modulate disease microenvironments. The system’s biocompatibility (probiotic strains and Lactobacillus) and scalability (cost-effective patch design) further support its potential for localized therapies (skin diseases and tumors) with minimized systemic exposure. This innovation bridges microbial biotechnology and precision medicine, offering a paradigm shift in transdermal delivery.

Original language	English
Article number	0775
Journal	Research
Volume	8
DOIs	https://doi.org/10.34133/research.0775
Publication status	Published - 2025
MoE publication type	B1 Article in a scientific magazine

Funding

Thanks to the Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine for their help.

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10.34133/research.0775Licence: CC BY

research.0775Final published version, 1.92 MBLicence: CC BY

https://urn.fi/URN:NBN:fi-fe2026022415850

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title = "In Situ: Microbial Aerodynamic Microneedles for Targeted Drug Delivery Systems",

abstract = "In situ microbial aerodynamic microneedles (MM-MNs) represent an autonomous transdermal drug delivery platform that utilizes the gas generated by microbial metabolism (e.g., H2, NO, and H2S) to propel drugs into deep tissues, surpassing the penetration limits of traditional microneedles reliant on external stimuli (heat/light/mechanical force). By leveraging controlled microbial metabolism, MM-MNs enable energy-independent, spatiotemporally precise delivery with enhanced targeting and bioavailability. Gas-driven propulsion combines with bioactive gas functions (e.g., NO-induced vasodilation and H2S-mediated anti-inflammation) to modulate disease microenvironments. The system{\textquoteright}s biocompatibility (probiotic strains and Lactobacillus) and scalability (cost-effective patch design) further support its potential for localized therapies (skin diseases and tumors) with minimized systemic exposure. This innovation bridges microbial biotechnology and precision medicine, offering a paradigm shift in transdermal delivery.",

author = "Chenyu Zong and Fei Wang and Wenguo Cui",

note = "Publisher Copyright: Copyright {\textcopyright} 2025 Chengyu Zong et al. Exclusive licensee Science and Technology Review Publishing House. No claim to original U.S. Government Works.",

year = "2025",

doi = "10.34133/research.0775",

language = "English",

volume = "8",

journal = "Research",

issn = "2096-5168",

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TY - JOUR

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T2 - Microbial Aerodynamic Microneedles for Targeted Drug Delivery Systems

AU - Zong, Chenyu

AU - Wang, Fei

AU - Cui, Wenguo

PY - 2025

Y1 - 2025

N2 - In situ microbial aerodynamic microneedles (MM-MNs) represent an autonomous transdermal drug delivery platform that utilizes the gas generated by microbial metabolism (e.g., H2, NO, and H2S) to propel drugs into deep tissues, surpassing the penetration limits of traditional microneedles reliant on external stimuli (heat/light/mechanical force). By leveraging controlled microbial metabolism, MM-MNs enable energy-independent, spatiotemporally precise delivery with enhanced targeting and bioavailability. Gas-driven propulsion combines with bioactive gas functions (e.g., NO-induced vasodilation and H2S-mediated anti-inflammation) to modulate disease microenvironments. The system’s biocompatibility (probiotic strains and Lactobacillus) and scalability (cost-effective patch design) further support its potential for localized therapies (skin diseases and tumors) with minimized systemic exposure. This innovation bridges microbial biotechnology and precision medicine, offering a paradigm shift in transdermal delivery.

AB - In situ microbial aerodynamic microneedles (MM-MNs) represent an autonomous transdermal drug delivery platform that utilizes the gas generated by microbial metabolism (e.g., H2, NO, and H2S) to propel drugs into deep tissues, surpassing the penetration limits of traditional microneedles reliant on external stimuli (heat/light/mechanical force). By leveraging controlled microbial metabolism, MM-MNs enable energy-independent, spatiotemporally precise delivery with enhanced targeting and bioavailability. Gas-driven propulsion combines with bioactive gas functions (e.g., NO-induced vasodilation and H2S-mediated anti-inflammation) to modulate disease microenvironments. The system’s biocompatibility (probiotic strains and Lactobacillus) and scalability (cost-effective patch design) further support its potential for localized therapies (skin diseases and tumors) with minimized systemic exposure. This innovation bridges microbial biotechnology and precision medicine, offering a paradigm shift in transdermal delivery.

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U2 - 10.34133/research.0775

DO - 10.34133/research.0775

M3 - Review Article or Literature Review

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SN - 2096-5168

VL - 8

JO - Research

JF - Research

M1 - 0775

ER -

In Situ: Microbial Aerodynamic Microneedles for Targeted Drug Delivery Systems

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